Surgery, chemotherapy, and photodynamic therapy have historically been the commonly applied in case of treating pancreatic cancer. Recently, nanoparticle technology as a novel approach is quite successful and focused more on this field as well. Few people with pancreatic cancer survive for more than ...
For instance, a personalized mRNA vaccine, autogene cevumeran (BNT122), has been developed for pancreatic cancer treatment in a phase I clinical trial [78]. The vaccine operates by using mRNA to express 20 neoantigens derived from patients with pancreatic ductal adenocarcinoma (PDAC), ...
Protein components of the ECM present an attractive target for the development of cancer therapies. Unlike cancer cells, the elements of ECM are rarely mutated and, therefore, are less susceptible to immune evasion [53]. Their stability and abundance in different types of solid tumors allow for ...
the number of new cases is anticipated to be 1.9 million by the end of the year 2021 [4]. The conventional therapeutic approaches used in cancer treatment include surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy
Rational design of smart nanosystems with high biological safety is a critical milestone for realizing precise imaging-guided cancer theranostics. Herein, a bioinspired nanosystem was designed by camouflaging SPIO@DOX-ICG nanoparticles with cancer cell m
cancer and melanoma. Moreover, it outcompeted conventional18F-2-fluorodeoxyglucose (FDG) PET/CT imaging in detecting pancreatic lesions of mice with pancreatic ductal adenocarcinoma (PDAC), demonstrating a higher signal-to-noise ratio and clarity [53]. Targeting CAR-T cells to the TME via an ...
Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enha
Triple-negative breast cancer (TNBC) is recognized as a particularly aggressive subtype of breast cancer that is devoid of effective therapeutic targets. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in TNBC treatment. Nonethele
Cancer immunotherapy has shown promising therapeutic results in the clinic, albeit only in a limited number of cancer types, and its efficacy remains less than satisfactory. Nanoparticle-based approaches have been shown to increase the response to immuno
pancreatic ductal adenocarcinoma (PDAC), administered via intravenous injection using lipid NPs (LNPs). Following treatment with this mRNA vaccine, the T cells in some patients with pancreatic cancer were activated for up to 3 years, and the immune response induced by the vaccine was linked to a...