微针(Microneedle, MNs)技术作为一种新型透皮药物递送方法,可以有效穿透皮肤角质层屏障,通过微米级细针快速将药物递送至皮肤深层,具有微创、无痛和自主给药等优势。本研究采用明胶(Gelatin, Gel)和京尼平制备不同交联度的交联明胶(Crosslinked ...
which avoid triggering nerves and thus minimize patient pain [32]. Microneedle-based delivery of nanoparticles can support transport across most physical barriers inside the body, precisely reach targeted sites with high efficiency, avoid clearance by the immune ...
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. Besides, the syringe needle can delivery drugs to acupoint, which combine with acupuncture. Hua et al. [160] found that the acupoint injection relieve the pain of the primary osteoporosis patients effectively, whose clinical efficacy was superior to the intramuscular injection. What's more, the...
dysfunction in an experimental interstitial cystitis/bladder pain syndrome (IC/BPS) [111]. 2.3.2Physicochemical stimuli Environmental parameters play a pivotal role in modulating physiological conditions that not only facilitate the production of EVs but can also enhance their therapeutic properties [106,...
Micronee- dles are microscale biomedical tools that can pain- lessly penetrate the stratum corneum layer and create microchannels on the skin. The fabrication strategies of microneedles include substrate manufacturing, formative manufacturing, and additive manufacturing. Micronee- dle-based electrodes ...