In contrast, 105 normal women of the same age without X-chromosome skewing, had no TET2 mutations.42 Mutation of DNMT3A occurs about fivefold more frequently in the normal elderly individuals than mutations of either TET2, IDH1/2, AXSL1, JAK2, SRSF2 or SF3B1 (to name a few). Many of...
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Clearly, more experience is required to determine at what stage these individual with germline preleukemic mutations need aggressive therapy. Monitoring their marrow for the acquisition of additional Driver mutations might prompt initiation of aggressive therapy such as allogenic hematopoietic stem cell trans...