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In contrast, 105 normal women of the same age without X-chromosome skewing, had no TET2 mutations.42 Mutation of DNMT3A occurs about fivefold more frequently in the normal elderly individuals than mutations of either TET2, IDH1/2, AXSL1, JAK2, SRSF2 or SF3B1 (to name a few). Many of...
Clearly, more experience is required to determine at what stage these individual with germline preleukemic mutations need aggressive therapy. Monitoring their marrow for the acquisition of additional Driver mutations might prompt initiation of aggressive therapy such as allogenic hematopoietic stem cell trans...
so there was humanity once but not anymore! what happened through the ages that pass by to reach this situation? everyone can consider this for a moment in their lives. 9. what's the story behind the title of "as the ages passing by..."? themis: it is our perspective for the world...
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women who also had chromosomal skewing of the X chromosome. In contrast, 105 normal women of the same age without X-chromosome skewing, had noTET2mutations.42Mutation ofDNMT3Aoccurs about fivefold more frequently in the normal elderly individuals than mutations of eitherTET2,IDH1/2, AXSL1,JAK2...