Drobes DJ, Anton RF, Thomas SE, Voronin K (2003). A Clinical Laboratory Paradigm for Evaluating Medication Effects on Alcohol Consumption: Naltrexone and Nalmefene. Neuropsychopharmacology 28: 755-764.Anton RF, Myrick H, Wright TM, Latham PK, Baros AM, Waid LR, Randall PK. Gabapentin ...
treatment with naltrexone resulted in a significantly reduced alcohol craving and alcohol consumption, with an approximately 50% lower incidence of relapse to heavy drinking (Volpicelli, Alterman, Hayashida, & O’Brien, 1992). In another 12-week, randomized controlled trial in 97 alcohol-dependent ...
consumption of opiates becomes pointless since effect of drug is neutralised. For decades alreadyNaltrexone pellet implant therapyis helping people in their fight against alcohol and drug dependence. Naltrexone treatment for alcoholism and drug addiction is actually an alternative therapy to methadone, ...
When used in conjunction with behavior modification, naltrexone reportedly decreases alcohol craving, reduces alcohol consumption, decreases the number of drinking days, maintains abstinence from alcohol ingestion, and prevents, decreases, or ameliorates the severity of relapse....
Injections (intraperitoneal) of acute (0, 50, 100, 200, 400 mg/kg) and chronic (2 脳 100 mg/kg, 10 days) acamprosate, or naltrexone (0, 1.0, 2.5, 5.0 mg/kg) were administered. Behavioral drug specificity was determined by comparing alterations in alcohol or water consumption in SIP ...
A study explored the combined effects of naltrexone and alcohol on cigarette cravings in heavy-drinking smokers. It was found that naltrexone reduced cigarette cravings in the context of alcohol consumption, suggesting that it could help smokers who also struggle with heavy alcohol use to reduce thei...
reducing the amount of alcohol consumed than producing complete abstinence;1 reports6 from patients who continued to drink during therapy suggest that naltrexone may reduce the pleasure associated with drinking, possibly by blocking the effect of endorphins released as a result of alcohol consumption. ...
Hypothalamic-Pituitary-Adrenocortical (HPA) Axis Response and Biotransformation of Oral Naltrexone: Preliminary Examination of Relationship to Family History of Alcoholism Andrea C. King, Ph.D., James Schluger, M.D., Mithat Gunduz, M.S., Lisa Borg, M.D., Guillaume Perret, M.D., Ann Ho,...
Like the mu-opioid receptor, these dopamine-processing genes can have small specific variations that result in slight differences in the strength of reward or pleasure signaling after alcohol consumption. In a clinical trial, Anton and his team genotyped 146 treatment-seeking alcohol use disorder pati...
27 In addition, a similar polymorphism has been reported to reduce alcohol-induced stimulation and alcohol consumption in nonhuman primates.28 However, as reported when this polymorphism was first described,19 a meta-analysis of human population studies suggested that this OPRM1 polymorphism is not ...