The following most frequently reported events (in decreasing frequency) have been identified primarily during postapproval use of naloxone hydrochloride (all routes of administration): withdrawal syndrome, vomiting, nonresponsiveness to stimuli, drug ineffective, agitation, somnolence, and loss of conscious...
Elzey MJ, Fudin J, Edwards ES. Take-home naloxone treatment for opioid emergencies: a comparison of routes of administration and associated delivery systems. Expert Opin Drug Deliv [Internet]. 2016 Sep 16 [cited 2017 Jan 13];1-14. Available from: http://www.tandfonline.com/doi/pdf/...
1,6,7 Due to challenges in conducting clinical efficacy trials in the community setting, these approvals were based on demonstrating that naloxone plasma concentrations are comparable to or greater than those achieved by approved, labeled routes of administration.8 Intranasal naloxone products are sold...
When naloxone hydrochloride is administered intravenously, the onset of action is generally apparent within two minutes. The time to onset of action is shorter for intravenous compared to subcutaneous or intramuscular routes of administration. The duration of action is dependent upon the dose and route...
(t1/2) 60–120 min] due to high clearance. Metabolites are inactive. Major routes for administration are intravenous, intramuscular, and intranasal, the latter primarily for take-home naloxone. Nasal bioavailability is about 50%. Nasal uptake [mean time to maximum concentration (Tmax) 15–30 ...
identified wide variation in levels of EMS personnel authorized to administer naloxone, dosing protocols, and routes of administration in recent years (Davis et al., 2014). For example, ALS personnel have always been authorized to administer naloxone in Wyoming, while ILS and BLS personnel received...
recommended by numerous federal, state, and professional organizations.Areas covered: The scope of the opioid overdose epidemic is reviewed along with practical, clinical, regulatory, and usability considerations for take-home naloxone routes of administration currently available and associated delivery ...
Take-home naloxone treatment for opioid emergencies: a comparison of routes of administration and associated delivery systemsAuto-injectorintranasal kitnaloxonenasal sprayopioid emergencyopioid overdoseopioid-induced respiratory depressionIntroduction: Naloxone reversal of opioid-induced respiratory depression outside...
When naloxone hydrochloride is administered intravenously, the onset of action is generally apparent within two minutes. The time to onset of action is shorter for intravenous compared to subcutaneous or intramuscular routes of administration. The duration of action is dependent upon the dose and route...
The data from the clinical abuse potential studies indicate that TARGINIQ ER has pharmacologic properties that are expected to reduce abuse via the intranasal and intravenous routes of administration. However, abuse of TARGINIQ ER by these routes is still possible. ...