The real-world findings, which were presented at the 2025 ASCO Gastrointestinal Cancers Symposium, demonstrated that treatment with FOLFIRINOX in a trial-aligned cohort of patients who met the eligibility criteria for the NAPOLI 3 trial (n = 219) elicited a median OS of 9.1 months (...
79 According to Table S1, the designed ligands meet all criteria for Lipinski’s rule of five and fall within the range of optimal LogD values (1.8–3.1) for drug molecules.80., 81. Further, base pK a values are below 10.5, ideal for CNS permeability and supportive of potential for ...
Main inclusion criteria are histologically proven mESCC after failure of first-line platinum-based chemotherapy and WHO performance status 鈮 2. Patients initially treated by surgery and chemotherapy or definitive chemoradiation are eligible if relapse occurred less than 6 months after the end of the...
Quality of life questionnaire-core 30; QoL: Quality of life; RECIST: Response Evaluation Criteria in Solid Tumors; SAE: Severe adverse event; TUDD: Time until definitive deterioration; ULN: Upper limit of normal; WHO: World health organization Competing interests Nanoliposomal-Irinotecan, 5-FU and...
Exclusion criteria were severe physical or mental disease or difficulties in under- standing the Swedish language, although exclusion for any of these factors never became necessary. The study sample was representative of the population in terms of educational attainment, immigrant status, and employment...
Eligibility criteria Inclusion criteria Patients will be eligible for inclusion if they are consist- ent will all of the following criteria: (1) adult patients (50–75 years of age) with significant knee pain (defined as pain score ≥ 40 mm on the 100mmVAS scale), (2) hav- ...
(1 : 1 : 1 ratio). The primary end point was OS; secondary end points included progression-free survival, time to treatment failure, and tumour reponse. The study’s full inclusion and exclusion criteria and findings can be found in the NAPOLI-1 primary publication (Wang-Gillam ...
Key Inclusion Criteria Adenocarcinoma of the exocrine pancreas Metastatic disease, measurable or non-measurable Progressed after prior gemcitabine or gemcitabine-containing therapy KPS ≥70 Adequate bone marrow, hepatic (bilirubin within normal range for the institution, and albumin ≥3 g/dL), and rena...
In order to obtain a diagnosis of FMF, a patient must have at least 1 major criterion, 2 minor criteria, 1 minor criterion with at least 5 supportive criteria, or 1 minor criterion with at least 4 of the first 5 supportive criteria. Three types of typical attacks constitute major criteria...
Therefore, our optimisation criteria were as follows: (i) we identified the post-annealing condition below 500 °C to maximise the Q factor. The increase in the A2 ordering leads to the formation of the pseudo-B2 phase, which is theoretically [5] and experimentally [10] predicted to exhibit...