生物世界/王聪 一直以来,裸鼹鼠(Naked mole rats)因为其长寿和抵抗衰老相关疾病(包括癌症、心血管疾病、神经退行性疾病)的强大能力而备受科学界关注,裸鼹鼠的寿命可达30-40岁,是同体型啮齿动物寿命的10倍以上,因此被用于研究衰老和长寿。 通过将一种负责增强细胞修复和保护的特定基因引入小鼠体内,罗彻斯特大学的研究人...
CancerCell transformationTumorigenesisXenograftIt is widely accepted that cancer is driven by genetic mutations that confer uncontrolled cell proliferation and tumor formation. For tumors to take hold and grow, cancer cells evolve mechanisms to favorably shape their microenvironment and avoid being cleared ...
Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destroy cells infected with pathogens and to provide an early...
You may find them visually abhorrent, but nocturnal, underground-dwelling naked mole rats are giving scientists clues on how to prevent or treat malignant cancers i…
Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destroy cells infected with pathogens and to provide an early...
Naked mole-rats (NMRs;Heterocephalus glaber) are highly adapted, eusocial rodents renowned for their extreme longevity and resistance to cancer. Because cancer has not been formally described in this species, NMRs have been increasingly utilized as an animal model in aging and cancer research. We...
Naked mole rats are unusual in many ways as a result of adaptations to living underground, with extreme longevity and a lack of the normal signs of aging. Their resistance to cancer has been linked to the production of a substance called high molecular mass hyaluronan (HMM-HA), and ...
The pALT(INK4a/b) protein found in naked mole rats that would be inserted into this bacteria is able to prevent tumors from developing. Cancer is the second most common cause of death in the US and is responsible for 1 of every 4 deaths. If a lot of this gene (and consequently the...
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Naked mole rats don’t get cancer Estimated Population Size Unknown, but they are of Least Concern Biggest Threat None Most Distinctive Feature They’re mammals but live much like social insects. Other Name(s) Sand puppy Gestation Period 70 days Litter Size 3 to as much as 28 pups Habitat ...