Reproduction, Sexual maturation, Aging, RNA-seq, Naked mole-rat, EusocialityBackground Naked mole-rats (NMRs) are eusocially organized in colonies. Although breeders carry the additional metabolic load of reproduction, they are extremely long-lived and remain fertile......
Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammalsdoi:10.1016/j.gene.2015.07.004CancerNaked mole ratSingle amino acid changeSequencePathwayBackground The naked mole rat (NMR, Heterocephalus glaber) is a long-lived rodent model with multiple extraordinary ...
Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is unclear if exceptional polymer length of vHMM-HA is important for longevity. Here, we show that vHMM-HA (>6.1 MDa) has superior ...
Background/Aims: The maximum lifespan of the naked mole rat is over 28.3 years, which exceeds that of any other rodent species, suggesting that age-related changes in its body composition and functionality are either attenuated or delayed in this extraordinarily long-lived species. However, the ...
The naked mole-rat (NMR; Heterocephalus glaber) is growing in popularity as a model for aging research due to its extreme longevity (up to 30 years), highly adapted physiology, and resistance to cancer, particularly when compared with traditional aging models such as laboratory mice and rats. ...
Background The naked mole-rat (NMR) is a long-lived and cancer resistant species. Identification of potential anti-cancer and age related mechanisms is of great interest and makes this species eminent to investigate anti-cancer strategies and understand aging mechanisms. Since it is known that the...
The naked mole-rat (NMR) is a subterranean rodent that has gained significant attention from the biomedical research community in recent years as molecular mechanisms underlying its unusual biology start to be unraveled. With very low external mortality, NMRs have an unusually long lifespan while ...
Background The unique biology of the naked mole-rat (NMR, Heterocephalus glaber) has fostered its increasing popularity as an animal model in a variety of research fields. This includes an exceptionally long lifespan and resistance to cancer [1, 2]. The Animal Ageing and Longevity Database (...
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity and are resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging according to a primary hallm
Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance, suggesting that their immune system might have evolved to facilitate these phenotypes. Natural killer (NK) and T cells have evolved to detect and destroy cells infec