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Furthermore, by extension of the sugar chains at the C3 or C4 hydroxyl group, derivatives including chitotriose thiazolines [25], Gal-β1,3-GlcNAc-thiazoline [26], [27] and Man9GlcNAc-thiazoline [28], [29] have been developed as potent inhibitors against GH18 chitinase, GH20 lacto-N-...
Excess of monofunctional alkyne afforded triazole derivatives substituted by a sugar unit at N-1 of the triazole moiety (Scheme 1). Half equivalent of the bifunctional alkyne linked two NAG-thiazoline moieties in an analogous way. The influence of the respective linkers attached to the triazole ...