doi:10.1016/0002-9149(88)90254-8John B. KostisElsevier Inc.American Journal of CardiologyKostis JB (1988) Comparison of the duration of action of atenolol and nadolol for treatment of angina pectoris. Am J Cardiol 62: 1171–1175
The long duration of action of nadolol and the fact that it is only 30% protein bound make it less desirable during pregnancy than other β-blockers such as propranolol. Nadolol crosses the rodent placenta. Rodent studies are generally reassuring, revealing no evidence of teratogenicity despite ...
It also prolongs AV monophasic action potentials. It is the longest-acting beta-blocker and its duration of action is up to 24 hours. Additionally, it is less lipid-soluble than other blockers and probably enters the central nervous system (CNS) to a lesser extent. Nadolol is almost like ...
DurationFollowing doses of 40–320 mg daily, duration of antihypertensive and antianginal effects is ≥24 hours.FoodFood does not affect the rate or extent of absorption.DistributionExtentWidely distributed; minimal amounts detected in the brain of dogs. Distributed into bile....
Mechanism of Action Blocks response to beta-adrenergic stimulation to beta1 and beta2 receptors; may reduce portal pressure through beta2 receptor, which reduces portal blood flow Pharmacokinetics Half-Life: 10-24 hr Onset: 3-4 hr Duration: 17-24 hr Vd: 1.9 L/kg (1.88-2.02 L/kg) Peak ...
duration of action, effects following a single dose of nadolol were long lasting, the 'pharmacological half-life' in some studies being about 40 hours.Pharmacokinetic Studies: The oral bioavailability of nadolol is about 30%, and appears to be unaltered in man by the presence of food in the...
Nadolol, a non-selective β-blocker with a long duration of action, reportedly is devoid of membrane stabilizing action. Since such action is augmented by ischaemic conditions, it was of interest to investigate whether, in simulated ischaemia, a direct membrane effect of nadolol might be ...
The duration of action of three beta blockers (atenolol in nine patients, nadolol in 18 patients, and pindolol in 11 patients) administered once a day was studied in three cohorts of patients with angina on effort. Compared with single-blind run-in placebo, all three beta blockers ...
Its long duration of action and the fact that it is only 30% protein bound make nadolol less desirable during pregnancy than other β-blockers such as propranolol. Nadolol crosses the rodent placenta. Rodent studies are generally reassuring, revealing no evidence of teratogenicity despite the use...
Described is the case of an infant, exposed during to the beta-blocker , who experienced cardiorespiratory , mild , and retardation. The longer duration of action of and the fact that it is only 30% bound make it less desirable than for use as a beta-blocker during pregnancy....