CoQ is a substituted l,4-benzoquinone containing a polyisoprenoid side chain at C6 (Figure 13.5). In bacteria, CoQ usually contains 6 isoprenoid units (Q6), whereas in most mammalian mitochondria it has 10 (Q10). The reduction of Q to QH2 (a hydroquinone) requires two electrons and two ...
Complex II, also known as succinate dehydrogenase, is a member of the TCA cycle (Chapter 12). It oxidizes succinate to fumarate, which is coupled to the reduction of FAD to FADH2. The electrons from FADH2are transferred to CoQ via Fe-S centers with the formation of CoQH2. ...
to the body. If the body has insufficient amounts of NADH, CoQ10 will deplete the NADH which has the double negative of making you extremely tired and also, the remainder of the CoQ10 ineffective. Sufficient NADH is required to alter CoQ10 into an antioxidant and an energy producing ...