参考文献：1. Navas LE, Carnero A. NAD+ metabolism, stemness, the immune response, and cancer. Sig Transduct Target Ther. 2021;6(1):20. 2. Mehmel M, Jovanović N, Spitz U. Nicotinamide riboside—the current state of research and therapeutic uses. Nutrients. 2020;12(6):1616.
2021年4月29日，Cell Metabolism在线发表了题为“Evolving concepts in NAD+ metabolism”的综述论文，梳理了NAD+这一领域的最新发现和概念，此外，本文提出了一些关于NAD生物学的开放性问题，包括为什么NAD的代谢在某些组织中如此快速和动态，NAD及其前体如何被运输到细胞和细胞器，NAD的代谢如何与炎症和衰老整合等等，...
NAD代谢是一个非常动态的过程,NAD在某些组织中的半衰期只有几分钟。事实上,NAD代谢失调已成为促进多种疾病发病的一个重要因素,“NAD-boosting”或“NAD-regenerative”疗法被提出可以作为治疗人类疾病的一种方法。2021年4月,梅奥医学中心的研究者在Cell Metabolism在线发表了一篇名为“Evolving concepts in NAD+ metaboli...
图4.NMN在人体临床试验中的安全性和抗衰老作用 参考文献：[1]Chini CCS, Cordeiro HS, Tran NLK, Chini EN. NAD metabolism: Role in senescence regulation and aging. Aging Cell. 2023 Jul 9:e13920.[2]Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS,...
Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice. Am J Cardiovasc Dis. 2017;7(2):33–47. Yoshida et al., 2019. Extracellular Vesicle-Contained eNAMPT Delays Aging and ...
瑞士洛桑联邦理工大学的Johan Auwerx教授等人曾在Nature Metabolism上在线发表题为NAD+homeostasis in health and disease 的综述,详细地为我们回顾了NAD+生物化学和代谢的基础知识,并讨论了NAD+研究目前在疾病中的治疗作用及转化潜力。 什么是NAD+? NAD+最初是通过调节酵母提取物...
近日,法国Gustave Roussy研究团队在《Circulation》发表了题为“NAD+ Metabolism in CardiacHealth, Aging, and Disease” 的综述文章。文章讨论了NAD+代谢的现状,以及NAD+的稳态受损如何加重常见的心脏代谢危险因素,从而促进心血管疾病的发生。然后,深入研...
[2] Covarrubias AJ, Perrone R, Grozio A, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141.[3] Yao H, Liu M, Wang L, et al. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) ...
[2] Covarrubias AJ, Perrone R, Grozio A, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. [3] Yao H, Liu M, Wang L, et al. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT)...
Lee JS et al. 2012. Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One. 2012;7(10):e47122. doi: 10.1371/journal.pone.0047122. Xin et al. 2018. Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P...