参考文献：[1]Yang S, Niou ZX, Enriquez A, LaMar J, Huang JY, Ling K, Jafar-Nejad P, Gilley J, Coleman MP, Tennessen JM, Rangaraju V, Lu HC. NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport. Mol Neurodegener. 2024 Jan 29;19(1):13. 本文内容...
烟酰胺腺嘌呤二核苷酸(NAD+/NADH)和烟酰胺腺嘌呤二核苷酸磷酸(NADP+/NADPH)氧化还原对是细胞内氧化还原状态的主要决定因素。 6) NAD drives ATP production in the cytosol by glycolysis and in themitochondria by oxidative phosphorylation, while the phosphorylated analogue NADP governs lipid, amino acid and n...
In this context, STAT1 binds to a conserved element within the first intron of NAMPT, termed NAMPT-Regulatory Element-1 (NRE1), and enhances its expression, thus driving aerobic glycolysis and initiating expressions of a subset of inflammatory genes in the tumor-associated macrophages stimulated ...
在生物体内，3-磷酸甘油醛转化为1,3-二磷酸甘油酸的关键步骤中，NAD+的充足供应是必不可少的。这个过程中，NAD+会经历还原反应，转化为NADH+H，它作为一个氢载体，将氢质子输送到后续的氧化呼吸链中。NAD+的再生过程主要依赖于两种关键酶的作用。首先，复合体1，作为呼吸链中的一个重要环节，它能...
[31] Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS (2018) Cardioprotection by nicotinamide mononucleotide (NMN): involvement of glycolysis and acidic pH. J Mol Cell Cardiol 121:155–162
NAD+ is involved in glycolysis, the citric acid cycle, fatty acid oxidation, etc. NAD+ accepts electrons from other molecules to form NADH, which then acts as a reducing agent to give electrons. 体外活性 方法:HEK293 细胞用 FK866 (2 µM) 和 NAD+ (100 µM) 处理 48 h,使用...
The combination of GAPDH- and LDH-type transfer reactions is also described here as a system mimic for the NAD+/NADH redox cycle in anaerobic glycolysis. GAPDH=D-glyceraldehyde-3-phosphate dehydrogenase, LDH=L-lactate dehydrogenase. Get PDF (110K) More content like this Find more co...
[7] Xucai Liao, Xi Chen, Xiangrun Li, et al. Nicotinamide mononucleotide improves spermatogenic function in streptozotocin-induced diabetic mice via modulating the glycolysis pathway. Acta Biochim Biophys Sin (Shanghai). 2022 Jul 25.
Glycolysis is the first step in the breakdown of glucose in cellular metabolism. It consists of an energy-requiring phase and an energy-releasing phase. In the process of glycolysis, NAD+ is reduced to form the NADH molecule. Krebs cycle The Krebs cycle is found in all cells that use oxyge...
[4] Cong, J., Wang, X., Zheng, X., Wang, D., Fu, B., Sun, R., … & Wei, H. (2018). Dysfunction of natural killer cells by FBP1-induced inhibition of glycolysis during lung cancer progression.Cell metabolism,28(2), 243-255....