蘋果酸酶 (Malic Enzyme; ME) 具有三種異構型,其中粒線體蘋果酸酶 (Mitochondrial NAD(P)+-dependent malic enzyme;ME2) 作用於快速增生的組織、小腸黏膜細胞、脾臟、胸腺與腫瘤細胞;ME2 催化受質蘋果酸 (Malate) 生成產物丙酮酸 (Pyruvate),同時伴隨產生NADH。NADH 在粒線體內膜電子傳遞鏈經氧化磷酸作用直接產生...
蘋果酸酶 ME2粒線體蘋果酸酶2(Mitochondrial NAD(P)+-dependent malic enzyme;ME2)通常表現於腫瘤細胞當中,在早期文獻中即指出與癌症的代謝有關, 但參與白血病細胞分化的機制尚不清楚.利用TPA誘導人類早幼粒細胞HL-60分化的過程中,我們發現過度表現粒線體蘋果酸酶的人類早幼粒細胞會降低巨噬細胞分化所造成的細胞...
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thereby upregulating activated T cell functions [115]. On the other hand, the modulation of mitochondrial NAD+/NADH levels can impact lysosome functions during inflammatory T cell responses. Conditional deletion of the mitochondrial transcription
Mitochondrial NAD(P)-dependent malic enzyme [EC 1.1.1.39, L-malate: NAD(+) oxidoreductase (decarboxylating)] was purified from herring testicular tissue to a specific activity of 26.4 μmol NADH/min/mg protein. Herring testicular tissue is one of the most abundant sources of this enzyme. The...
Malic enzyme (Mitochondrial NAD(P)+ -dependent malic enzyme;ME2)According to the early studied, ME2 is associated with cancer metabolism, but mechanisms involved in the induced differentiation of leukemia cells are still unknown. In process of differentiating HL-60 cells by using TPA., we found ...
Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) has a dimer of dimers quaternary structure with two independent allosteric sites in each monomer. Here, we reveal the different effects of nucleotide ligands on the quaternary structure regulation and functional role of the human ...
mitochondrial NADPH, which elevates the reduced GSH levels.138Simultaneously, SIRT3 can not only induce the expression of antioxidant enzymes by activating the FOXO3a, but also enhance the activation of SOD2 and catalase via NAD+-dependent deacetylation.139,140Besides SIRT3-mediated deacetylation, ...
Immunolocalization of NAD-dependent 11 β -hydroxysteroid dehydrogenase in human kidney and colon. The inactivation of physiological glucocorticoids by 11... Z Kyossev,Patrick D. Walker,WB Reeves - 《Kidney International》 被引量: 142发表: 1996年 NAD- and NADP-dependent mitochondrially targeted met...
Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme. Hsieh JY, Liu JH, Fang YW, Hung HC (2009) Dual roles of Lys57 at the dimer interface of human mitochondrial NAD(P) + -dependent malic enzyme . ... H Jörnvall,J Hempel,BL Vallee...