研究结果表明，正常小鼠在高脂饮食后，体内的NAD+含量显著下降，而CD38基因缺失小鼠则不会在高脂饮食下出现NAD+水平的下降。这意味着高脂饮食会通过增加CD38的含量来降低NAD+水平，从而影响小鼠的身体健康。同时，研究人员发现，正常小鼠高脂饮食之后，其中枢神经内的少突质细胞数量显著得开始减少。 这一点是与《生物...
参考文献 [1] Castro K, Ntranos A,Amatruda M, et al. Body Mass lndex in Multiple Sclerosis modulates ceramide-induced DNAmethylation and disease course.(2019).EBioMedicine 43:392-410. [2] ] Langley MR, Choi Cl, Peclat TR, et al. Critical Role of Astrocyte NAD+ Glycohydrolase in Myelin...
并且与安慰剂相比，这种改善是显着的（Castro-Marrero，Antioxid Redox Signal 2015）。
CAFD-diet obese wistar rat 400 mg/kg/d,4 weeks, oral; Muscle mass↑ (de Castro et al., 2021) Human Aged individuals with antioxidant deficiencies(71.5 ± 1 years old) A single dose of 500 mg Muscle strength↑. (Dolopikou et al., 2020) Human with experimental muscle injury...
这一策略的发现，为开发新的延缓衰老和延长寿命的疗法提供了科学依据。参考 Jin H, Li M, Jeong E, Castro-Martinez F, Zuker CS. A body-brain circuit that regulates body inflammatory responses. Nature. 2024 May 1. doi: 10.1038/s41586-024-07469-y. Epub ahead of print. PMID: 38692285.
Castro, R. E. et al. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 58, 119–125 (2013). Article CAS PubMed Google Scholar Choi, S.-E. et al. Elevated microRNA-...
[19] Castro-Marrero, J., Cordero, M. D., Segundo, M. J., Sáez-Francàs, N., Calvo, N., Román-Malo, L., … Alegre, J. (2015). Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome? Antioxidants & Redox Signaling, ...
这一策略的发现,为开发新的延缓衰老和延长寿命的疗法提供了科学依据。 参考 Jin H, Li M, Jeong E, Castro-Martinez F, Zuker CS. A body-brain circuit that regulates body inflammatory responses. Nature. 2024 May 1. doi: 10.1038/s41586-024-07469-y. Epub ahead of print. PMID: 38692285....
R. Castro-Portuguez, G.L. Sutphin Kynurenine pathway, NAD+ synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and healthspan Exp Gerontol, 132 (2020), Article 110841, 10.1016/j.exger.2020.110841 View PDFView articleGoogle Scholar [59] L. Rajman, K. Chwa...
Nat Metab, 2019, 1(1): 8-9 [18] Castro-Portuguez R, Sutphin GL. Kynurenine pathway, NAD+ synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and health- span. Exp Gerontol, 2020, 132: 110841 [19] Lee Y, Lee HY. Revisiting the bacterial phylum ...