关键字:nacubactam;那库巴坦;OP-0595; RO 7079901 ;RG 6080;1452458-86-4 ; 公司简介 河北唯特医药科技有限公司专注于苯并杂环Block,抗生素增强剂(Antibiotic enhancer)的研发和生产,尤其以β内酰胺酶抑制剂类管线的药物为业务主线,提供阿维巴坦(Avibactam),瑞莱巴坦(Relebactam),齐德巴坦(Zidebactam),WCK-5153,等...
To analyse the impact of the most clinically relevant β-lactamases and their interplay with low outer membrane permeability on the activity of cefiderocol, ceftazidime/avibactam, aztreonam/avibactam, cefepime/enmetazobactam, cefepime/taniborbactam, cefepime/zidebactam, imipenem/relebactam, meropenem/va...
Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs[1][2]. non-β-lactam-β-lactamase[1] [1]. Monogue ML, et al. In Vivo Efficacy of Meropenem with a ...
OP0595RG6080carbapenemaselung epithelial lining fluidnacubactamNacubactam is a novel, broad-spectrum, beta-lactamase inhibitor that is currently under development as combination therapy with meropenem. This study evaluated the efficacy of human-simulated epithelial lining fluid (ELF) exposures of ...