Thus, the drug should now be considered a well established member of this group of agents for the treatment of painful rheumatic and inflammatory conditions. Pharmacodynamic Properties Nabumetone possesses the typical pharmacodynamic properties of the nonsteroidal class of anti-inflammatory drugs. Its ...
Nabumetone, with the chemical formula C15H16O2 and CAS registry number 42924-53-8, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, inflammation, and stiffness caused by conditions such as arthritis. It belongs to the class of drugs known as selective COX-2 ...
nonsteroidal anti-inflammatory,nonsteroidal anti-inflammatory drug,NSAID- an anti-inflammatory drug that does not contain steroids; "NSAIDs inhibit the activity of both Cox-1 and Cox-2 enzymes" ketone- any of a class of organic compounds having a carbonyl group linked to a carbon atom in each...
Nabumetone (Relafen) is approved for rheumatoid arthritis, osteoarthritis, and pain management. Its long half-life allows for once-daily dosing. Although this drug is a weak inhibitor of COX, it is metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6-MNA), a strong COX inhibitor ...
Thus, the drug should now be considered a well established member of this group of agents for the treatment of painful rheumatic and inflammatory conditions. Pharmacodynamic Properties Nabumetone possesses the typical pharmacodynamic properties of the nonsteroidal class of anti-inflammatory drugs. Its ...
Singh G, Mithal A, Triadafilopoulos G. Both selective cox-2 inhibitors and non-selective NSAIDs increase the risk of acute myocardial infarction in patients with arthritis: selectivity is with the patient, not the drug class. Annual European Congress of Rheumatology (EULAR); 2005 Jun 8–11; ...
naphthyl-alkanonesclass.Nabumetoneismetabolizedto anactivemetabolite,6-methoxy-2-naphthylaceticacid (6-MNA),whichisexcretedinurine.Both,drugand metabolite,bindextensivelytoalbuminplasma[1]. Nabumetone,acommerciallyavailabledrug,isreportedas beinglessaggressiveasfarassecondaryeffectsareconcerned ...
Nabumetone is a nonsteroidal anti-inflammatory drug ( NSAID ) of the 2,6-disubstituted naphthyl-alkanone class. Nabumetone is metabolised to an active me... NM Davies - 《Clinical Pharmacokinetics》 被引量: 193发表: 1997年 Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxy...
drugthatrequiresconversiontoanactivemetabolite6-methoxy- 2-naphthylaceticacid(6-MNA)foritsanti-inflammatory,anal- gesic,andantipyreticactivity.NabumetoneistheonlyNSAID oftheaceticacidclasswithahalf-lifelongenoughtosup- portoncedailyadministration.6-MNAcompetitivelyinhibits bothcyclooxygenase(COX)isoenzymes,COX...
Define Novo-Nabumetone. Novo-Nabumetone synonyms, Novo-Nabumetone pronunciation, Novo-Nabumetone translation, English dictionary definition of Novo-Nabumetone. n. An anti-inflammatory and analgesic drug of the NSAID class, C15H16O2, used primarily to tre