该研究揭示了白蛋白结合型紫杉醇（Nab-PTX）与免疫检查点阻断疗法（ICB）联合治疗三阴性乳腺癌（TNBC）的独特细胞机制，为优化TNBC治疗方案提供了新视角。研究背景TNBC作为乳腺癌中最难治性的亚型，因其缺乏特定的分子靶点，治疗方案极为有限。化疗，尤其是紫杉醇（PTX）及其改良形式Nab-PTX，仍是TNBC的主
NABPTX化疗方案是以纳米化紫杉醇(Nab-paclitaxel)为主要药物的化疗方案。该方案通常用于乳腺癌、非小细胞肺癌和胰腺癌等多种恶性肿瘤的治疗。纳米化紫杉醇是一种通过把传统的紫杉醇纳米化而得到的新型抗癌药物。 二、NABPTX化疗方案的作用机制 NABPTX化疗方案的作用机制主要包括两个方面。首先,纳米化紫杉醇能够通过改变...
Background The standard treatment of relapsed small cell lung cancer (SCLC) has not been established yet, and weekly paclitaxel (PTX) is recommend as one of the treatment options for relapsed SCLC. In advanced non-small cell lung cancer, nanoparticle albumin-bound paclitaxel (nab-PTX) has ...
在T 细胞方面,Nab-PTX + ATZ 治疗使效应记忆 CD8+ T 细胞(Tsem)和 CD4+ T 滤泡辅助细胞(Tfh)增多,并抑制 T 细胞耗竭;PTX + ATZ 治疗对 T 细胞的影响则有所不同,且在阻断 T 细胞耗竭上效果欠佳。在其他免疫细胞方面,Nab-PTX + ATZ 治疗后髓细胞减少,而 PTX 治疗后 T 细胞和 NK 细胞增加。同时,研...
Cy5-Nab-PTX 荧光标记白蛋白结合型紫杉醇 是由西安齐岳生物科技有限公司提供科研类试剂 货号规格数量价格 Q-0097320100mg 1 询价 Q-0097320250mg 1 询价 Q-0097320500mg 1 询价 Q-00973201g 1 询价 Q-00973205g 1 询价 快速订购/大包装咨询 张惠宁销售经理 ...
Though prescribed as first-line drugs for esophageal squamous cell cancer (ESCC) therapy, the antitumor efficacy of Nab-Paclitaxel (Nab-PTX) is still unsatisfactory owing to the limitation on the dosage and therapy duration of Nab-PTX caused by adverse effects. Inspired by the very essential role...
Background: Nab-paclitaxel (nab-PTX) has been shown to improve outcome of patients with metastatic breast cancer (MBC) when compared to conventional taxanes. Aiming to determine how the clinical practice treatment results compare with the evidence-based data, we analyzed patterns of treatment and ...
Methods Two hundred patients with pancreatic cancer who received GEM + nab-PTX were retrospectively investigated. Frequency and risk factor(s) of suspension of the treatment and grade 3/4 neutropenia in the first course were evaluated. Results The frequency of treatment suspension in the first ...
Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was developed to improve the therapeutic index of taxane treatment. However, the ABSOLUTE trial showed the non- inferiority of weekly nab-PTX (w-nab-PTX) to wPTX with respect to overall survival (OS) as second-...
A phase Ib extension study of cancer stemness inhibitor BB608 (napabu- casin) in combination with gemcitabine and nab-paclitaxel (nab-PTX) in patients (pts) with metastatic pancreatic cancer. Poster presented at: ASCO 2016 Annual Meeting [abstract 4128]. 71. Bahary N, Garrido-Laguna I, ...