NAA10/ARD1 基因概述 NAA10 gene / cDNA is a protein-coding gene which located on Xq28. The NAA10 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, and frog.168 organisms have orthologs with human gene NAA10. ...
Ogden syndromeX-linked disorderOgden syndrome is an exceptionally rare X-linked disease caused by mutations in the NAA10 gene. Reported cases of this syndrome are approximately 20 children and are associated with facial dysmorphism, growth delay, developmental disorders, congenital heart disease, and ...
The NAA10 gene lies in the gene-rich region Xq28 and is composed of 8 exons (NM_003491.3; Figure 1a). It is highly expressed in the developing brain of mice embryos1 and shows a lower yet uniform and ubiquitous expression in adult mice.2 Complete knockout is lethal in Trypanosoma brucei...
中文名称:Anti-NAA10 Polyclonal Antibody 英文名称:Anti-NAA10 Polyclonal Antibody Gene ID: 8260 Public Immunogen Range: Recombinant protein of human NAA10 Subcellular Locations: Cytoplasm Nucleus Swiss Prot: P41227 保存: Store at -20°C. Avoid freeze / thaw cycles. 别名: TE2;ARD1;NATD;ARD1A;...
cDNA microarray of Naa10 gene function also indi- cated the morphogenesis role of Naa10. Tube formation is a reflection of vasculogenesis or angiogenesis, increased tube formation ability was observed upon Naa10 down expression. Measuring the different time points of gene expression upon Naa10 ...
and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript ...
4E). When FIH was silenced, the target gene expressions were enhanced due to the blockade of HIF-1α N803 hydroxylation. However, they were no more regulated by NAA10 knockdown because NAA10 was not capable of acetylating HIF-1α without FIH. Under hypoxia, the target genes were highly ...
the first human genetic disorder caused by a mutation in a NAT gene was reported; boys diagnosed with the X-linked Ogden syndrome harbor a p.Ser37Pro (S37P) mutation in the gene encoding Naa10, the catalytic subunit of the NatA complex, and suffer from global developmental delays and letha...
and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript ...
The gene encoding hNaa16p originates from an early vertebrate duplication event from the common ancestor of hNAA15 and hNAA16. Immunoprecipitation coupled to mass spectrometry identified both endogenous hNaa15p and hNaa16p as distinct interaction partners of hNaa10p in HEK293 cells, thus ...