Gene ID: 8260 种属 Homo sapiens DNA序列编号: NM_003491.4 DNA描述 Homo sapiens N-alpha-acetyltransferase 10, NatA catalytic subunit (NAA10), transcript variant 1, mRNA DNA大小: 1603 bp DNA编码区: atgaacatccgcaatgcgaggccagaggacctaatgaacatgcagcactgcaacctcctc tgcctgcccgagaactaccagatgaaatactacttct...
N-末端乙酰化(N-terminal acetylation, NTA)是体内最常见的蛋白质修饰之一,Naa10基因(N-α-terminal acetyltransferuse gene 10)在人体细胞内广泛表达,参与蛋白质乙酰化修饰,在调控机体病理生理等生物学进程中扮演重要的角色[2]。研究发现Naa10基因表达异常不但与个体发育畸形、阿尔兹海默症、帕金森病等疾病有关[3-...
NAA10/ARD1 基因概述 NAA10 gene / cDNA is a protein-coding gene which located on Xq28. The NAA10 gene is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, and frog.168 organisms have orthologs with human gene NAA10. ...
Ogden syndromeX-linked disorderOgden syndrome is an exceptionally rare X-linked disease caused by mutations in the NAA10 gene. Reported cases of this syndrome are approximately 20 children and are associated with facial dysmorphism, growth delay, developmental disorders, congenital heart disease, and ...
The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase (NAT) gene. The affected males harbour a Ser37Pro mutation in the gene encoding hNaa10, the ca... LM Myklebust,VD Petra,Stve Svein I,... - 《Hu...
The NAA10 gene lies in the gene-rich region Xq28 and is composed of 8 exons (NM_003491.3; Figure 1a). It is highly expressed in the developing brain of mice embryos1 and shows a lower yet uniform and ubiquitous expression in adult mice.2 Complete knockout is lethal in Trypanosoma brucei...
中文名称:Anti-NAA10 Polyclonal Antibody 英文名称:Anti-NAA10 Polyclonal Antibody Gene ID: 8260 Public Immunogen Range: Recombinant protein of human NAA10 Subcellular Locations: Cytoplasm Nucleus Swiss Prot: P41227 保存: Store at -20°C. Avoid freeze / thaw cycles. 别名: TE2;ARD1;NATD;ARD1A;...
目的 探讨醋酸阿比特龙联合多西他赛与泼尼松在转移性去势抵抗性前列腺癌(mCRPC)患者中的应用及N-末端α位乙酰基转移酶基因10(acetyltransferase gene 10,Naa10)与治疗敏感性的关系。方法 回顾性选择2017年10月-2019年12月邢台医学高等专科学校第二附属医院收治的122例mCRPC患者为研究对象,入选患者均经过雄激素剥夺治疗。
cDNA microarray of Naa10 gene function also indi- cated the morphogenesis role of Naa10. Tube formation is a reflection of vasculogenesis or angiogenesis, increased tube formation ability was observed upon Naa10 down expression. Measuring the different time points of gene expression upon Naa10 ...
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females. Eur J Hum Genet. 2015;23(5):602–9. Article CAS PubMed Google Scholar Valentine V, Sogawa Y, Rajan D, Ortiz D. A case of de novo NAA10 mutation presenting with eyelid ...