Sodium calcium exchangerCalciumHeart contractilityExcitation contraction couplingHeart failureGenetically modified miceNCX transports Ca in and out of the cell in exchange for Na, controlling Ca homeostasis.Changes in Na concentration alter the driving force for Ca efflux by NCX.Reduced Ca efflux by NC...
Insulin was found to stimulate Na +-dependent Ca 2+ uptake in dog heart sarcolemma in a concentration dependent manner (0.001 to 1 milliunits/ml). Maximal stimulations (160 to 170%) was seen at 0.1 to 1 milliunits/ml of insulin. Unlike Na +-dependent Ca 2+ uptake, ATP-dependent Ca ...
Analysis of Na(+)/Ca (2+) exchanger (NCX) function and current in murine cardiac myocytes during heart failure. Xu L;Chen J;Li XY;.Analysis of Na(+)/Ca(2+)exchanger(NCX)function and current in murine cardiac myocytes during heart failure.Mol Biol Rep... L Xu,J Chen,XY Li,......
Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M et al (1995) Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. Genomics 25(3):615–622 CAS PubMe...
The Na+/Ca2+ exchanger was first identified nearly three decades ago in heart [1] and in nerves [2]. It has been identified in virtually every tissue by functional tests or by molecular or immunological techniques [3–12]. The Na+/Ca2+ exchanger is locat
The Na +/H + exchanger (NHE) is involved in intracellular pH homeostasis of many mammalian cell types. To date seven NHE isoforms (NHE1–NHE7) have been identified. NHE1 is the most predominant isoform expressed in heart where it contributes to cardiomyocyte pH homeostasis. Although the NHE...
Immunofluorescence localization of the Na-Ca exchanger in heart cells We investigated the localization of the Na-Ca exchanger in fixed, isolated heart cells from rat and guinea pig using immunocytochemical methods with epiflu... RS Kieval,RJ Bloch,GE Lindenmayer,... - 《American Journal of Physio...
There was a positive correlation between Na(+)-Ca2+ exchanger and SR Ca(2+)-ATPase mRNA levels both in normal and failing human hearts, albeit with different slopes and intercepts of the regression line. The Na(+)-Ca2+ exchanger protein levels as assessed by Western blot analysis and ...
The stoichiometry with which the Na/Ca exchanger, NCX1, binds and transports Na and Ca has dramatic consequences for ionic homeostasis and cellular function of heart mycocytes and brain neurons, where the exchanger is highly expressed. Previous studies have examined this question using native NCX1...
The Na+/Ca2 + exchanger is a unique mechanism allowing Ca2+ extrusion from the cell against its gradient without consuming any energy. The Na+/Ca2+ exchanger has been recently cloned and this has offered new research possibilities to better investigate this transporter and to use it to improve...