钠钙交换体（Na+/Ca2+ Exchangers，NCX）是一种Na+/Ca2+交换器，负责细胞中大部分Ca2+的外流1-3。NCX 转运蛋白是溶质载体 SLC8 家族的成员，而 SLC8 家族又属于 CaCA（Cation-Coupled Antiporter）超家族1,4,5。NCX-1 是三种Na+/Ca2+交换器（NCX-1、NCX-2、NCX-3）之一，可实施一次 Ca2+ 跨质膜...
然而,细胞内的 Ca2+ 浓度比细胞外环境低 1000 倍,保持这一比例对细胞的正常功能至关重要。钠钙交换体(Na+/Ca2+ Exchangers,NCX)是一种Na+/Ca2+交换器,负责细胞中大部分Ca2+的外流1-3。NCX 转运蛋白是溶质载体 SLC8 家族的成员,而 SLC8 家族又属于 CaCA(Cation-Coupled Antiporter)超家族1,4,5。 NCX...
钠钙交换体(Na+/Ca2+ Exchangers,NCX)是一种Na+/Ca2+交换器,负责细胞中大部分Ca2+的外流1-3。NCX 转运蛋白是溶质载体 SLC8 家族的成员,而 SLC8 家族又属于 CaCA(Cation-Coupled Antiporter)超家族1,4,5。 NCX-1 是三种Na+/Ca2+交换器(NCX-1、NCX-2、NCX-3)之一,可实施一次 Ca2+ 跨质膜移动,...
2011. High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cor- tex affected by Alzheimer's disease. Cell Calcium 49:208-16.S. Sokolow, S. H. Luu, A. J. Headley et al., "High levels of synaptosomal Na+-Ca...
Orexin能够直接兴奋STN神经元,该效应是通过激活突触后OXlR和OX2R及它们所耦联的Na+-Ca2+交换体(Na+-Ca2+exchangers)和内向整流性型钾离子通道实现的。与组胺不... 李光英 - 南京大学 被引量: 0发表: 2019年 破骨细胞内钠/钙交换体(Na+/Ca2+exchanger,NCX)的表达及其在骨吸收中的作用 目的钠/钙交换体(...
Electrophysiological characterization shows that the conserved residues within transmembrane segments 2 and 7, coordinating Na+ and Ca2+ ions in NCX_Mj, play a fundamental role in NCX1.1. Our results suggest a similar architecture between the mammalian and archaebacterial exchangers. 展开 ...
题外话，这个特性与组织细胞的缺血-再灌注损伤的钙超载也有关，也就是NHE和NCX的耦联。缺氧胞内酸中毒时，NHE把H排出，Na+泵入，而胞内Na+浓度高了会刺激NCX排Na，吸收Ca2+。信号通路机制如下图 摘自 Na+/H+ Exchangers in Renal Regulation of Acid-Base Balance 另外，闰细胞上的H⁺-K⁺交换体和H...
Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3). Three distinct mammalian Na+/Ca2+ exchangers have been cloned: NCX1, NCX2, and NCX3. We have undertaken a detailed functional comparison of these three exc... B Linck,Z Qiu,Z He,... - ...
the countertransport of three Na for one Ca across plasma membrane by the Na+/Ca2+ exchanger (NCX); Increase of exchange activities of NCX1 and NCX3 by agents activating protein kinases A and C; Similarities of the affinities for transported ions of Na+ and Ca2+ for the three exchanger...
Na+/Ca2+ Exchangers 来自 Springer 喜欢 0 阅读量: 24 作者: L Annunziato 摘要: SynonymsSynonymsSodium calcium exchanger; Na+/Ca2+ exchanger; Na+/Ca2+ antiporter; NCX; NCX1; NCX2; NCX3DefinitionDefinitionThe plasma membrane Na+/Ca2+ exchanger is a highヽapacity and low affinity i DOI...