此外,野生型METTL1而非其无催化活性的突变体的过表达增加了总m7G tRNA修饰水平和m7G修饰tRNA的表达,证明了METTL1通过其tRNA m7G甲基转移酶活性调控tRNA修饰和表达(图3H)。同样,抑制WDR4导致m7G修饰水平降低,在K150和K30 ESCC细胞中,过表达WDR4增加了m7G tRNA修饰和m7G修饰的tRNA表达(图3I和J)。这些数据均表明了...
【文献精选——文献精读】Role of N7-methylguanosine (m7G) in cancer(N7-甲基鸟苷(m7G)在癌症中的作用) N7-甲基鸟苷(m7G)是表观遗传调控过程中发生的一种重要RNA修饰。越来越多的研究证明,m7G在抑制癌症方面的作用值得关注。在此,我们基于m7G相关癌症的现有研...
N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancerAutophagyesophageal squamous cell carcinomam7GMETTL1tRNA modificationMacroautophagy/autophagy, a physiological process that is involved in tumorigenesis, is regulated at genetic and epigenetic levels. Emerging reports suggest that...
stability, and function9,10. Dysregulated tRNA modifications are frequently associated with developmental diseases and cancers8,11. N7-methylguanosine (m7G) is a common
Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity, which is crucial for translation. We describe how tRNA N7-methylguanosine (m7G46) methylation, catalyzed by METTL1-WDR4, regulates translation and influences senescence phenotypes. Mettl1/Wdr4 and m7G gradually diminish...
N7-methylguanosine modification participates in multiple mRNA disorders that impact tumor regression. Check the SLC7A7 for the existence of the m7g modifier via the m7g-hub website (Fig. 6E). According to the results of the me-RIP, the anti-m7g antibody concretely enriched SLC7A7 mRNA in ...
Growing evidence indicates that N7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing coccidiosis in
Growing evidence indicates that N7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing coccidiosis in
Mutations modification enzymes including the tRNA N7-methylguanosine (m7G) methyltransferase complex component WDR4 were frequently found in patients with neural disorders, while the pathogenic mechanism and therapeutic intervention strategies are poorly explored. In this study, we revealed that patient-...
The efficacy of single or combined therapy with anti-PD-1 antibody, gene knockout and chemical inhibitor were evaluated in vivo.Results Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are enriched in advanced ICCs and significantly correlated with N7-methylguanosine (m7G) tRNA ...