【文献精选——文献精读】Role of N7-methylguanosine (m7G) in cancer(N7-甲基鸟苷(m7G)在癌症中的作用) N7-甲基鸟苷(m7G)是表观遗传调控过程中发生的一种重要RNA修饰。越来越多的研究证明,m7G在抑制癌症方面的作用值得关注。在此,我们基于m7G相关癌症的现有研...
与tracseq数据一致,m7G northwestern和northern实验证实,METTL1敲除细胞中m7G修饰水平降低,m7G修饰trna表达减少(图3G)。此外,野生型METTL1而非其无催化活性的突变体的过表达增加了总m7G tRNA修饰水平和m7G修饰tRNA的表达,证明了METTL1通过其tRNA m7G甲基转移酶活性调控tRNA修饰和表达(图3H)。同样,抑制WDR4导致m7G修饰水...
识别N7-甲基鸟苷相关的lncRNAs以用于肝细胞癌的风险分层(Identification of N7-methylguanosine-related lncRNAs for the risk stratification of hepatocellular carcinoma) 肝细胞癌(Hepatocellular carcinoma, HCC)是世界上最常见的恶性肿瘤之...
N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancerAutophagyesophageal squamous cell carcinomam7GMETTL1tRNA modificationMacroautophagy/autophagy, a physiological process that is involved in tumorigenesis, is regulated at genetic and epigenetic levels. Emerging reports suggest that...
11. N7-methylguanosine (m7G) is a common tRNA modification that is highly conserved in prokaryotes, eukaryotes, and some archaea12. Different from many essential tRNA modifications, the m7G tRNA modification is non-essential for yeast growth and survival under normal conditions, but is required ...
Growing evidence indicates that N7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing coccidiosis in
As an essential post-transcriptional modification, N-7-methylguanosine (m7G) regulates nearly every step of the life cycle of mRNA. Accurate identification of the m7G site in the transcriptome will provide insights into its biological functions and mechanisms. Although the m7G-methylated RNA immunopreci...
Moreover, we identified the presence of N7-methylguanosine (m7g) modification on SLC7A7 and that the degradation rate of SLC7A7 was regulated by the m7g recognition protein QKI. Our results indicate that SLC7A7 has the potential to promote tumor progression and serve as a potential therapeutic...
Moreover, we identified the presence of N7-methylguanosine (m7g) modification on SLC7A7 and that the degradation rate of SLC7A7 was regulated by the m7g recognition protein QKI. Our results indicate that SLC7A7 has the potential to promote tumor progression and serve as a potential therapeutic...
Growing evidence indicates that N7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing coccidiosis in