(1)拟南芥gDNA中4acC修饰的特征 为了确定gDNA中4acC的存在,我们使用一种特异性识别mRNA中ac4C碱基的抗体,通过免疫印迹分析检测了4acC,该抗体已用于mRNAs中ac4C位点的全基因组分析。在免疫-Southern blot试验中,用RNase-A去除gDNA中的RNA,用凝胶电泳分离可能残留的RNA。从含有0.2 μg纯化gDNA的凝胶中很容易检测到4a...
N4-acetylcysteine (ac4C) is a chemical modification in mRNAs that alters the structure and function of mRNA by adding an acetyl group to the N4 position of cytosine. Researchers have shown that ac4C is closely associated with the occurrence and development of various cancers. The...
andN6-methyladenosine (m6A)/N6-methyldeoxyadenosine (6mA), are detected in both RNA and DNA, respectively. The modified baseN4-acetylcytosine (ac4C) is well studied in
13]. The coding sequence of mRNA near its polyA tail is enriched with ac4C residues, and their abundance decreases in the 5′ to 3′ direction corresponding to that of gene transcription. The ac4C-enriched mRNAs has
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6,44,45 N4-acetylcytosine acetylation is the acetylation of cytosine at position N4 in the presence of RNA ac4C-modifying enzymes.8 In the field of covalent modification of proteins, studies have suggested that acetylation/deacetylation is the second most important covalent modification factor, which...
Furthermore, ac4C is co-related with the progression, prognosis, and development of several human diseases4. Recently, Arango et al.3 reported that NAT10 acetyltransferase is involved in the catalyzation of N4-acetyl-cytidine (ac4C) as an mRNA modification5. Whole transcriptome mapping of ac4C ...
Furthermore, we demonstrated that CLIC3 could inhibit NAT10-catalyzed ac4C modification, but not the binding of NAT10 to p21 mRNA, which may be associated with the interaction between CLIC3 and the N-acetyltransferase domain of NAT10. Notably, CLIC3 could inhibit the acetylation of Cytosine at...
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RNA modification has emerged as an important epigenetic mechanism that controls abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of RNA N4-acetylcytidine (ac4C) modification in AML remain elusive. Here, we report that a