N4-acetylcytidine (ac4C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is significantly associated with various human diseases, especially cancer, and its formation depends on the catalytic activity of N-ace...
Abstract RNA modification has emerged as an important epigenetic mechanism that controls abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of RNAN4-acetylcytidine (ac4C) modification in AML remain elusive. Here, we report that ac4C and its catalytic enzyme NAT10 dr...
Conformational characteristics of 4-acetylcytidine found in tRNA. Nucleic Acids Symp Ser. 1989;(21):61–2. Kumbhar BV, Kamble AD, Sonawane KD. Conformational preferences of modified nucleoside N(4)-acetylcytidine, ac4C occur at "wobble" 34th position in the anticodon loop of tRNA. Cell Biochem...
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression Yujun Shuai, Hui Zhang, Changhao Liu, Junting Wang, Yangkai Jiang, Jiayin Sun, Xincheng Gao, Xiaochen Bo, Xingyuan Xiao, Xin Liao, Chao Huang, Hebing Chen...
N4-acetylcytidine m5C: 5-methylcytosine m1A: N1-methyladenosine m6A: N6-methyladenosine m7G: 7-methylguanosine ψ: pseudouracil ac4Cm: N4-acetyl-2′-O-methylcytidine ac6C: N6-acetyladenosine HPLC: High-performance liquid chromatography LC-MS: ...