Transfer RNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes N2,N2-dimethylguanine formation at position 26 (m(2)(2)G26) in tRNA. In the reaction, N2-guanine at position 26 (m(2)G26) is generated as an intermediate. The trm1 genes are found only in archaea and eukaryotes, ...
Two sister strains of Saccharomycea cerevisiae are described which lack the base N2-dimethylguanine in their sRNA; apart from this omission, the distribution of methylated bases in the sRNA is similar to that in the sRNA from a variety of other S. cerevisiae mutants. Enzyme preparations from ...
Roe B, Michael M, Dudock B. Function of N2 methylguanine in phenylalanine transfer RNA. Nat New Biol. 1973 Dec 5; 246 (153):135–138.Roe, B.. Michael, M., and Dudock, B. Function of N2-methylguanine in phenylalanine transfer RNA. Nature (Lond.), 246: 135-137. 1973....
coli tRNA showed that, in the case of the liver tumors, the increased formation of N 2- dimethylguanine was much greater than that of the other methyl bases. With the kidney tumor, a similar change in the pattern of methylation was obtained. Extracts of liver regenerating after partial ...