which have been shown to decrease innate immunogenicity and can additionally increase mRNA stability, both of which are favourable characteristics for mRNA therapies1,2,3,4,5. For example, clinically approved SARS-CoV-2 mRNA vaccines incorporateN1-methylpseudouridine (1-methylΨ), which has been s...
RIBONUCLEIC ACIDS CONTAINING N1-METHYL-PSEUDOURACILS AND USES THEREOFThe present disclosure provides RNAs containing one or more modified nucleotides, wherein 100% of uracils are replaced with N1-methyl-pseudouridine.SCHRUM, JASON PSIDDIQI, SUHAIB...
Promoted read-through and mutation against pseudouridine-CMC by an evolved reverse transcriptase Zhiyong He Weiqi Qiu Huiqing Zhou Communications Biology(2025) MSCAN: multi-scale self- and cross-attention network for RNA methylation site prediction ...
groove binding partner; c) bringing the provided cDNA and the selected nucleotide into contact with an RNA polymerase under such conditions that the RNA is synthesized, the nucleotide being N1-methylpseudouridine and wherein 100% of the uracils in the RNA are replaced by N1-methylpseudouridine....