该研究报道了醋酸钯催化大位阻N-对甲基苯磺酰保护亚胺的不对称氢化: 1、简介 空间受阻底物的不对称氢化仍然是不对称催化领域的一个长期挑战。 大位阻的手性胺化合物,广泛应用于生物活性化合物、药物、配体的不对称合成制备中: 亚胺C=N基团上碳原子连接小位阻的取代基,例如甲基、乙基等,已经广泛地应用于不对称氢化...
1996年,Charette和Giroux描述了钌催化N-tosylines的不对称氢化反应,其产物的产率分别为82%、80%、<5%,对映体过量分别为62%、84%、17%,R取代基分别为甲基、乙基和异丙基(R ' = Ph)。由此可见,随着取代基团位阻增大,反应收率和对映选择性急剧下降。 2006年和2007年,Zhang和Zhou研发团地开发了三氟乙酸钯催化的...
N- tosylimines have been successfully synthesized for the first time by condensations of N -tosylamine with aldehydes catalyzed by HY3, HY6, HY9 and HZSM-5 zeolites. HY9 was the best catalyst, leading to the highest yield of N- tosylimines, indicating that the reaction efficiency depends ...
Gao, F,Deng, M,Qian, C.The effect of coordination on the reaction of N-tosyl imines with diethylzinc.Tetrahedron. 2005Gao, F.; Deng, M.; Qian, C., The effect of coordination on the reaction of N-tosyl imines with diethylzinc. Tetrahedron 2005, 61 (52), 12238-12243....
Baris Temelli,Dilek Isik Tasgin,Canan Unaleroglu.The reaction of N -tosyl imines with heteroaromatic compounds: a new access to triheteroarylmethanes[J]. Tetrahedron .2010(34)The reaction of N -tosyl imines with heteroaromatic compounds: a new access to triheteroarylmethanes[J] . Baris Temelli...
A convenient synthesis of N-tosylimines 来自 ACS 喜欢 0 阅读量: 53 作者:BM Trost,C Marrs 摘要: ChemInform is a weeklying Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInformof an article which was published elsewhere, ...
Initially, a model asymmetric hydrogenation of (Z)-t-butyl phenylN-tosylimines (1a) was carried out under 40 atm H2pressure at room temperature in TFE using Pd(TFA)2. The commonly used ligand, (R)-BINAP, could catalyze this reaction but only gave the desired hydrogenation product with ...
A Highly Enantioselective, Pd–TangPhos-Catalyzed Hydrogenation of N-TosyliminesThis work was supported by the National Institutes of Health (GM58832) doi:10.1002/anie.200600263Angewandte Chemie International EditionQin YangGao ShangWenzhong GaoJingen DengXumu Zhang...
A Highly Stereoselective Addition of the Anion Derived from α-Diazoacetamide to Aromatic N-TosyliminesThanks are due to Cheng Peng, Shufeng Chen, and Wei Qian for their valuable experimental contributions. Y.Z. and Z.M. contributed equally to this work. T doi:10.1002/ange....
Highly enantioselective Rh-catalyzed alkenylation of imines: synthesis of chiral allylic amines via asymmetric addition of potassium alkenyltrifluoroborate... For the first time, simple N-tosyl aryl aldimines are used as substrates in the rhodium catalyzed 1,2-addition reaction with alkenylboron ...