网络N-端乙酰化;端乙醯化作用 网络释义
Here, we investigate the role of a post-translational modification, N-terminal acetylation, in aSyn neurotoxicity. N-terminal acetylation occurs in all aSyn molecules and has been proposed to determine its lipid binding and aggregation capacities; however, its effect in aSyn stability/neurotoxicity ...
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an irrev
acetylation by N-terminal acetyltransferases (NATs)2,3. Acetylation transforms a charged protein N-terminus into a hydrophobic segment, thereby potentially affecting key protein properties such as folding, polymerization, stability, interactions, and localization. Given the prevalence of Nt-acetylation, ...
文章通过壳聚糖的N-乙酰化反应制备了不同脱乙酰度的壳聚糖。 更多例句>> 3) N-terminal acetyltransferase N末端乙酰基转移酶4) N acetylation N-乙酰化反应5) N acetylate N-乙酰化合物6) N acetyltransferase phenotype N-乙酰化分型补充资料:3-(N-乙酰乙酰)氨基-4-甲氧基乙酰苯胺 分子式:暂无分子量:...
Here, we show that N-terminal acetylation in combination with a mild purification protocol results in an oligomeric form of AS with partial -helical structure. N-terminal acetylation of AS could have important implications for both the native and pathological structures and functions of AS. Through...
N-terminal acetylation has been suggested to play a role in the subcellular targeting of proteins, in particular those acetylated by the N-terminal acetyltransferase complex NatC. Based on previous positional proteomics data revealing N-terminal acetylation status and the predicted NAT substrate classes...
Here, we show that N-terminal acetylation in combination with a mild purification protocol results in an oligomeric form of AS with partial α-helical structure. N-terminal acetylation of AS could have important implications for both the native and pathological structures and functions of AS. ...
Protein N-terminal acetylation by Nα-acetyltransferases (NATs) is an omnipresent protein modification that affects a large number of proteins. The exact biological role of N-terminal acetylation has, however, remained enigmatic for the overall majority of affected proteins, and only for a rather sm...
N-terminal acetylation is a protein modification common in eukaryotes, but rare in prokaryotes. Here, we characterized five mammalian stathmin-like subdomains expressed in Escherichia coli by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoESI Q-TOF tandem mass spectr...