N-Terminal acetylation is critical for forming ␣-helical oligomer of ␣-synuclein. Protein Sci. 21, 601-605.Trexler AJ, Rhoades E (2012) N-Terminal acetylation is critical for forming α-helical oligomer of α-synuclein . Protein Sci 21 : 601–605doi: 10.1002/pro.2056...
Acetylation of protein N-termini underlies several key biological processes. Although NatC acetylates hundreds of different substrates, we know very little about the functional and physiological importance of these acetylation events. While the genes encoding the human NatA and NatB subunits are mostly ...
网络N-端乙酰化;端乙醯化作用 网络释义
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an irrev
Acetylation transforms a charged protein N-terminus into a hydrophobic segment, thereby potentially affecting key protein properties such as folding, polymerization, stability, interactions, and localization. Given the prevalence of Nt-acetylation, NATs regulate a wide range of cellular processes, ranging ...
N-terminal acetylation of AS could have important implications for both the native and pathological structures and functions of AS. Through our demonstration of a recombinant expression system, our results represent an important step toward biochemical and biophysical characterization of this potentially ...
N-terminal acetylation (Nt-acetylation) is a highly abundant protein modification in eukaryotes and impacts a wide range of cellular processes, including protein quality control and stress tolerance. Despite its prevalence, the mechanisms regulating Nt-acetylation are still nebulous. Here, we present ...
Here, we show that N-terminal acetylation in combination with a mild purification protocol results in an oligomeric form of AS with partial α-helical structure. N-terminal acetylation of AS could have important implications for both the native and pathological structures and functions of AS. ...
N-terminal acetylationN-terminal acetyltransferaseParvalbuminMost eukaryotic proteins are N-terminally acetylated (Nt-acetylated) by specific N-terminal acetyltransferases (NATs). Although this co-/post-translational protein modification may affect different aspects of protein functioning, it is typically ...
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol 2003; 325: 595–622. Article CAS PubMed Google Scholar Hershko A, Heller H, Eytan E, Kaklij G, Rose IA . Role of the alpha-amino group of protein in ubiquitin-mediated ...