In conclusion, NatC-mediated N-terminal acetylation acts as a protective mechanism against protein degradation, which is relevant for increased longevity and motility.Nature Communications
S. (2018) Control of protein degradation by N-terminal acetylation and the N-end rule pathway. Exp Mol Med 50, 91Kha, N. T., Mun, S.-H., Lee, C.-S., & Hwang, C.-S. Control of protein degradation by N-terminal acetylation and the N-end rule pathway. Exp. Mol. Med. https...
N-terminal acetylation (Nt-acetylation) is a highly abundant protein modification in eukaryotes catalyzed by N-terminal acetyltransferases (NATs), which transfer an acetyl group from acetyl coenzyme A to the alpha amino group of a nascent polypeptide. Nt-acetylation has emerged as an important ...
网络N-端乙酰化;端乙醯化作用 网络释义
N-terminal acetylation (Nt-acetylation) is a highly abundant protein modification in eukaryotes and impacts a wide range of cellular processes, including protein quality control and stress tolerance. Despite its prevalence, the mechanisms regulating Nt-acetylation are still nebulous. Here, we present ...
Acetylation transforms a charged protein N-terminus into a hydrophobic segment, thereby potentially affecting key protein properties such as folding, polymerization, stability, interactions, and localization. Given the prevalence of Nt-acetylation, NATs regulate a wide range of cellular processes, ranging ...
Protein N-terminal acetylation by N α -acetyltransferases (NATs) is an omnipresent protein modification that affects a large number of proteins. The exact biological role of N-terminal acetylation has, however, remained enigmatic for the overall majorit
N-terminal acetylationN-terminal acetyltransferaseParvalbuminMost eukaryotic proteins are N-terminally acetylated (Nt-acetylated) by specific N-terminal acetyltransferases (NATs). Although this co-/post-translational protein modification may affect different aspects of protein functioning, it is typically ...
文章通过壳聚糖的N-乙酰化反应制备了不同脱乙酰度的壳聚糖。 更多例句>> 3) N-terminal acetyltransferase N末端乙酰基转移酶4) N acetylation N-乙酰化反应5) N acetylate N-乙酰化合物6) N acetyltransferase phenotype N-乙酰化分型补充资料:3-(N-乙酰乙酰)氨基-4-甲氧基乙酰苯胺 分子式:暂无分子量:...
N-terminal acetylation of AS could have important implications for both the native and pathological structures and functions of AS. Through our demonstration of a recombinant expression system, our results represent an important step toward biochemical and biophysical characterization of this potentially ...