solid-phase hydrolysis of the p-nitroanilide of n-succinyl-l-phenylalanine in the presence of chymotrypsinogendoi:10.1007/BF00923678N. V. MedvedevaYu. I. KhurginKluwer Academic Publishers-Plenum PublishersBulletin of the Academy of Sciences of the USSR Division of Chemical Science...
(R is 16C alkyl) is brought into contact with ammonia having 0.5-100 equivalent, preferably 0.8-70 equivalent at 10-180°C, especially 20-160°C under atmospheric pressure or higher pressure, especially 3-30 pressure to provide the objective N-(aminosuccinyl)phenylalanine alkylester of formula ...
PURPOSE: To efficiently produce the subject compound which is a precursor for producing aspartame using inexpensive maleic anhydride instead of L- aspartic acid necessary to introduce a selective protecting group.WATANABE MASATO渡辺 真人SETO KOJI瀬戸 弘司KANO YOSHIAKI加納 芳明SAITO TOSHIHIRO斉藤 寿広...