On the other hand, the amine groups on the peptide N-terminus or the lysine/arginine side chain are nucleophilic and reactive under neutral or slightly basic conditions, which makes them potential targets for palmitoylation. It is thus important to investigate whether palmitoyl migration from a ...
Structure‐directed mutagenesis indicates a critical role for arginine at position 203 in transmembrane domain 5 to mediate GPR132 activation by ‐acylamides. Our data suggest distinct modes of binding for small‐molecule and lipid agonists to the GPR132 receptor. Antagonists, such as those described...