However, alkynyl carbenes cannot be isolated by this route because they readily undergo intramolecular cyclization to pyrazoles as soon as formed from alkynyl N-tosylhydrazones. Here, the use of alkynyl N-nosylhydrazones for the in situ generation of alkynyl carbenes and their coupling reaction with...
The formation of a pyrazole byproduct is a problem in the decomposition reaction of alkynyl-N-sulfonylhydrazones to release alkynyl diazomethanes. This problem has been resolved by using alkynyl-N-nosylhydrazones, and further applied to coupling with boric acids leading to allenes. For more ...
N-nosylhydrazonessilverThe [2+1] cycloaddition of alkynes with diazo compounds represents one of the most powerful and reliable methods for the construction of cyclopropenes. However, it remains a formidable challenge to accomplish the cyclopropenation of alkynes with non-stabilized diazoalkanes, owing...
SilverThe cross-olefination reaction of donor and acceptor diazo compounds was explored. The use of N-nosylhydrazones as diazo surrogates and the dependence on silver catalysis were crucial for the reaction development. A variety of (hetero)aryl N-nosylhydrazones and 伪-diazo esters, amides, and ...
N-nosylhydrazonessilverp> N -Nosylhydrazones were discovered as the first generation ofroom-temperature decomposable diazo surrogates, which led to the development of silver-catalyzed [2+1] cyclopropenation of alkynes with unstable diazoalkanes. More information can be found in the Communication by X...
Herein, we report a general silver-catalyzed cyclopropenation reaction of alkynes with unstable diazoalkanes, by for the first time the discovery and application of N-nosylhydrazones as room-temperature decomposiable diazo surrogates. This method allows for the efficient assembly a wide variety of ...
The cross‐olefination reaction of donor and acceptor diazo compounds is reported. The use of N‐nosylhydrazones as the diazo surrogates and the dependence on silver catalysis are crucial for the reaction development. A variety of (hetero)aryl N‐nosylhydrazones and α‐diazo esters, amides, and...