In this paper, a novel series of N-hydroxybenzimidazoles as potential anticancer agents were designed and synthesized. The in vitro enzymatic assays suggested N-hydroxy-6-(3-nitrophenyl)-benzimidazole-2-carboxylic acid had good inhibitory potency (IC50 = 0.25 mu M) to human lactate dehydrogenase ...
Acetylation of 1H-2-(alpha-hydroxyalkyl/aryl) benzimidazoles 2 with Ac2O results in the regiospecific formation of O-acetoxy derivative 3, which on alkylation with alkylating agents in nonaqueous media under phase-transfer catalytic conditions affords N-alkyl derivatives 4. The latter, on hydrolysis ...
Novel benzimidazoles of the formula (in which either R is a group of the formula (Ia) or a pyridyl or (lower alkyl)-pyridyl group and one of the symbols Ra, Rb, Rc and Rd is lower alkyl, lower alkoxy, halogen, CF3, NO2, NH2, di-lower alkyl-amino, lower alkanoyl or sulphamo...
N-HYDROXY-BENZIMIDAZOLES, THEIR PREPARATION AND USE AS HERBICIDESHANS ROCHLINGOTTO SCHERER
N-Phenacyl-N-p-tolylsulphonyl-o-nitroanilines (8) are cyclised to 2-alkoxybenzimidazole N-oxides ( 2-alkoxy-N-hydroxybenzimidazoles)(13)鈥 (16) by sodium alkoxides in the appropriate alcohol. N-Phenacyl-o-nitroanilines themselves undergo cleavage, or at best give low yields of 2-benzoyl...
The present invention is concerned with new N-hydroxy benzimidazoles and their use as herbicidally active compounds.doi:US3681376 AScherer, OttoRochling, HansUSUS3681376 * Jun 16, 1969 Aug 1, 1972 Hoechst Ag -n-hydroxy-2-trifluoromethyl benzimidazoles and carbamic esters thereof...
ChemInform Abstract: A Quantitative 15 N NMR Investigation of Tautomeric Equilibria of Two 1-Hydroxybenzimidazolesmagnetic resonance, nuclear quadrupole resonance (organic substancesNo abstract is available for this article.doi:10.1002/chin.198624049
-N-HYDROXY-2-TRIFLUOROMETHYL BENZIMIDAZOLES AND CARBAMIC ESTERS THEREOFThe present invention is concerned with new N-hydroxy benzimidazoles and their use as herbicidally active compounds.OTTO SCHERERHANS ROCHLING
N-methylsulphonamido or N, N-dimethylsulphonamido substituted on one or more positions of the benzene ring of the quinoxaline, excluding the compounds 2-carbomethoxy-3- hydroxy quinoxaline-di-N-oxide and 2-carboethoxy-3-hydroxy quinoline-di-N-oxide; where X is as in Formula XI where X an...
K. SrinivasJohn Wiley & Sons, LtdChemInformDubey, P. K.; Prasada Reddy, P. V. V.; Srinivas, K. Alternate method for the synthesis of N-alkyl=aralkyl-2-(a-hydroxy alkyl=aralkyl)benzimidazoles via regiospecific acetylation. Synth. Commun. 2007, 37, 1675-1681....