Our data suggest that the use of IgG N-glycosylation analysis with matched N-glycan biosynthesis gene profiles may provide useful biomarkers for monitoring response to therapy and interventions. They also indicate potential gene modifying steps in this N-glycan biosynthesis pathway, of relevance to ...
Mucin-type O-glycan biosynthesis is regulated by the family of UDP-GalNAc polypeptide:N-acetylgalactosaminlytransfersases (ppGalNAcTs) that catalyzes the first step in the pathway by transferring GalNAc to Ser or Thr residues in a protei... Hazuki E. Miwa,Thomas A. Gerken §,Oliver Jamison...
Interestingly, WecA, the initiating GlcNAc transferase involved in enterobacterial common antigen and O-antigen biosynthesis can substitute for C. jejuni PglC function however, preferring UDP-GlcNAc rather than UDP-diNAcBac as the initiating monosaccharide61. Although pglC (on pACYC184pglmut) and ...
Tet-induced Mgat1, Mgat5 and Mgat6 combined with stimulation of hexosamine biosynthesis pathway (HBP) to UDP-GlcNAc, increased cellular metabolite levels, lactate and oxidative metabolism in an additive manner. We then tested the hypothesis that N-glycan branching alone might promote nutrient ...
This enzyme is capable of trimming high mannose oligosaccharides to Man5GlcNAc2 duringN-glycan biosynthesis. Human α1,2-mannosidase IC requires calcium for activity and is inhibited by 1-deoxymannojirimycin and kifunensine; thus, it possesses the characteristic properties of class I α1,2-...
De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate turnover and dietary sources also makes a significant contribution to the intracell
Processing glycosidases play an important role in N-glycan biosynthesis in mammalian cells by trimming Glc3Man9GlcNAc2 and thus providing the substrates fo... A Herscovics - Biochimica et Biophysica Acta (BBA) - General Subjects 被引量: 433发表: 1999年 Enhancement of fruit shelf life by supp...
Giant DNA virus mimivirus encodes pathway for biosynthesis of unusual sugar 4-amino-4,6-dideoxy-d-glucose (Viosamine) J. Biol. Chem, 287 (2012), pp. 3009-3018 10.1074/jbc.M111.314559 22157758 View PDFView articleView in ScopusGoogle Scholar 34 F. Piacente, C. De Castro, S. Jeudy, M...
The solution NMR structure of glucosylated N‐glycans involved in the early stages of glycoprotein biosynthesis and folding Glucosylated oligomannose N-linked oligosaccharides (GlcxMan9GlcNAc2 where x = 13) are not normally found on mature glycoproteins but are involved in the e... AJ Petrescu,...
The biosynthesis of highly branched N-glycans: studies on the sequential pathway and functional role of N-acetylglucosaminyltransferases I, II, III, IV, V and VI. Biochimie 70, 1521–1533 (1988). 80. Ihara, Y. et al. cDNA cloning, expression, and chromosomal localization of human N-...