3级胺与酰卤反应生成酰胺盐后,从N原子上脱酰基化的反应。 基本文献 反应机理 反应实例 实验步骤 实验技巧 参考文献
3级胺与酰卤反应生成酰胺盐后,从N原子上脱酰基化的反应。 基本文献 反应机理 反应实例 实验步骤 实验技巧 参考文献
A hypothesis that lipoxygenase may mediate N-dealkylation of xenobiotics was investigated using the prototype drug aminopyrine and soybean lipoxygenase as a model enzyme in the presence of hydrogen peroxide. Formaldehyde production as a result of N-demethylation of aminopyrine exhibited pH optimum of ...
The capacity of several opioid agonists and their N-dealkylated derivatives (normetabolites) to substitute for the discriminative and reinforcing stimulus properties of codeine was evaluated in rhesus monkeys, and the affinity of these compounds in binding to mu receptors in rhesus monkey brain membrane...
Herein we report the development and biological screening of a bioorthogonal palladium-labile prodrug of the nucleoside analogue floxuridine, a potent antineoplastic drug used in the clinic to treat advanced cancers. N-propargylation of the N3 position o
Mechanistic evaluation of N-dealkylation by cytochrome P450 using N,N-dimethylaniline N-oxides and kinetic isotope effects Cytochrome P450 enzymes (P450) are a large family of heme-containing monooxygenases found throughout nature. Five isoforms in humans have gained the attent... KM Roberts - Disse...
有机合成百科 N-甲酰化脱烷基化反应(N-carbamoylation-dealkylation)有机合成百科N-甲酰化脱烷基化反应(N-carbamoylation-dealkylation)2015/9/4 有机合成百科 铵盐 Author: LuWenjie 概要 3级胺与酰卤反应生成酰胺盐后,从N原子上脱酰基化的反应。 基本文献 反应机理 反应实例 实验步骤 实验技巧 参考文献 本...
N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in th...
N-Dealkylation of aliphatic amines and selective synthesis of monoalkylated aryl amines. Highly selective alkyl transfer processes of mono-, di- and trialkyl amines in the presence of the Shvo catalyst have been realized; in addition, a general... D Hollmann,B?hn, Sebastian,A Tillack,... ...