of uronic acid and Nacetylglucosamine and are modified by the same sulfotransferases (1, 2). The uronic acid residues can be sulfated at the 2O position by heparan sulfate 2O sulfotransferase (HS2ST). The ...
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. Heparan sulfate N-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory step in the biosynthesis of heparan sulfates and heparin. The c... Y Kakuta,T Sueyoshi,M Negishi...
1. Study on Effect of Compound Danshen Dropping Pill on N-acetyltransferase Activity in Human; 复方丹参滴丸对人N-乙酰基转移酶活性的影响 2. Relationship between genetic polymorphism of N-acetyltransferase and genetic susceptibility to Parkinson s disease; N-乙酰基转移酶基因多态性与帕金森病遗传易患...
Heparan sulfate/heparin N-deacetylase/N-sulfotransferase. The N-sulfotransferase activity domain is at the carboxyl half of the holoenzyme. P. Berninsone,C.B. Hirschberg. Journal of Biological Chemistry . 1998Microscale separation of heparosan, heparan sulfate and heparin[J] . Xue Zhao,Bo Yang,...
Disturbed Ca[sup2+] kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes. 2003b . Disturbed calcium kinetics in N -Deacetylase/ N -Sulfotransferase-1 and -2 Defective Myotubes . J Cell Sci 116 : 2187 – 2193 (DOI: 10.1242... Jenniskens,Guido,J.,... - 《Journal of Cell ...
SHI X,SU S,LONG J,et al.MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in hu-man gastric carcinoma cell line MGC803. Acta Biochim Bio-phys Sin (Shanghai) . 2011MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in hu-man ...
Furthermore, combining the individually expressed N-deacetylase and N-sulfotransferase domains produced different sulfation patterns when compared with that made by the NDST-1 enzyme. Our data demonstrate the essential role of domain cooperation within NDST-1 in producing HS with specific domain ...
Here, we determine cryo-electron microscopy structures of human N-deacetylase-N-sulfotransferase (NDST)1, the bifunctional enzyme primarily responsible for initial GlcNS modification of HS. Our structures reveal the architecture of both NDST1 deacetylase and sulfotransferase catalytic domains, alongside a...
Dagalv A, Holmborn K, Kjellen L and Abrink M: Lowered expression of heparan sulfate/heparin biosynthesis enzyme N‑deacetylase/N‑sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem 286: 44433‑44440, 2011....
Dagalv A, Holmborn K, Kjellen L and Abrink M: Lowered expression of heparan sulfate/heparin biosynthesis enzyme N‑deacetylase/N‑sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem 286: 44433‑44440, 2011....