N-acylsulfonamideanticanceragentssulfonamideN-Acylsulfonamides, with the general formula shown as compound 1, are claimed to act as low micromolar inhibitors of BCL-Xl, an antiapoptotic protein that has been demonstrated to play a very important role in a variety of cancers. The synthesis and ...
N-acylsulfonamide derivatives; BCL-X1 protein inhibitors; anticarcinogenic agents; bladder cancer; for example, N-(4-(4-((4'-chloro(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)-propyl)amino)-3-nitrobenzenesulfonamideUS 7973161 ...
Herein, we describe a LD chemistry usingN-acyl-N-alkyl sulfonamide derivatives (LDNASA) as the electrophilic reactive group (Fig.1b). Detailed kinetic analyses of in vitro protein labelling are conducted and compared with other LD reagents, revealing that the reaction rate of the labelling proces...
PURPOSE: To obtain a new N-acylarylsulfonamide useful as a stabilizer of highly sensitive heat-sensitive sheet excellent in heat resistance, water resistance and oil resistance. ;CONSTITUTION: An N-acyl-arylsulfonamide of the formula (R<Sub>1</Sub> to R<Sub>6</Sub> are H, 1-4C alkyl,...
Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK ... Masaharu Kawano,Syunsuke Murakawa,Kenji Higashiguchi,... 被引量: 0发表: 0年 Lysine-Reactive NAcylNaryl Sulfonamide Warheads: Improved Reaction...
对50个单元构成的聚N,N-二乙基丙烯酰胺(PDEA)低聚物的水溶液体系进行了分子动力学的研究,分别模拟了300 K时的伸展链、310 K时的伸展链以及紧缩链与水构成的体系,对溶液中PDEA周围溶剂水分子的分布情况以及水分子形成氢键的情况进行了统计,结果表明在PDEA周围的水产生了比本体水更有序的结构,形成了更多的氢键,这...
analogifremgangsmde for the manufacture of n - acyl or n - organosulfonyl - sulfamoylbenzensulfonamider or alkali metal, alkali earth, ammonium or amine sa... analogifremgangsmde for the manufacture of n - acyl or n - organosulfonyl - sulfamoylbenzensulfonamider or alkali metal, alkali ...
TRIBUTINO J L M,DUARTE C D,CORREA R S,et al. Novel 6-methanesulfonamide-3,4-methyl enedioxy phen-yl-N-acylhydrazones : orally effective anti-inflammatory drug candidates [ J ]. Bioorg. Med. Chem. , 2009,17 ( 3 ) : 1125-1131....
Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein ...
Described herein are herbicidal compositions comprised of a thiocarbamate or haloacetanilide herbicide and an antidotally effective amount of an N-acylsulfonamide compound corresponding to the formula ##STR1## in which R is selected from the group consisting of hydrogen, methyl, chloro, acetamido, ...