Deleterious variants in N-acetylneuraminate pyruvate lyase (NPL) cause skeletal myopathy and cardiac edema in humans and zebrafish, but its physiological role remains unknown. We report generation of mouse models of the disease: NplR63C, carrying the human p.Arg63Cys variant, and Npldel116 with...
The gene for N-acetylneuraminate lyase [N-acetylneuraminate pyruvate-lyase; NPL] of Escherichia coli C600 was cloned onto pBR322 as a 9.8 kilobase HindIII fragment of chromosomal DNA and the hybrid plasmid was designated pMK2. The gene in the hybrid plasmid was subcloned in pBR322 as a ...
English Name: Nana aldolase; N-Acetylneuraminate Pyruvate Lyase; N-Acetylneuraminic Acid Lyase; Sialic Aldolase; N-Acetylneuraminic Acid Aldolase Other name: N-acetylneuraminate aldolase Grade:BR Specific activity:≥50unit/mg protein Definition of vitality: one unit will release 1.0 μ mole of ...
N-acetylneuraminate lyase catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetyl-D-mannosamine. The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. The reverse reaction can be exploited for the synthesis of sialic ...
Simple and large-scale production of N-acetylneuraminic acid from N-acetyl-d-glucosamine and pyruvate using N-acyl-d-glucosamine 2-epimerase and N-acetylneuraminate lyase 文档格式: .pdf 文档大小: 108.18K 文档页数: 4页 顶/踩数: 0/0 ...
英文名称:NPL/N-acetylneuraminate lyase抗体 中文名称唾液酸醛缩酶NPL抗体 别名0610033B02Rik; C112; C1orf13; Dihydrodipicolinate synthase; Dihydrodipicolinate synthetase homolog 1; MGC149582; MGC61869; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NAL;...
1; MGC149582; MGC61869; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase;Anti-NPL/N-acetylneuraminate lyase抗体 NAL; NALase; NPL; NPL_HUMAN; NPL1; RP11-249O6.1; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase...
N-Acetylneuraminate lyases (NALs) or sialic acid aldolases catalyze the reversible aldol cleavage of N- acetylneuraminic acid (Neu5Ac) to form pyruvate and N-acetyl-D-mannosamine (ManNAc). In nature, N- acetylneuraminate lyase occurs mainly in pathogens. However, this paper describes how ...
"Configuration of substrate and products of N- acetylneuraminate pyruvate-lyase from Clostridium perfringens." Biochem Biophys Res Commun 111(2): 668-74.Deijl, C. M., and J. F. Vliegenthart. 1983. Configuration of substrate and products of N-acetylneuraminate pyruvate-lyase from Clostridium ...
N-Acetyl-d-neuraminic acid lyase (NanA) catalyzes the breakdown of sialic acid (Neu5Ac) to N-acetyl-d-mannosamine (ManNAc) and pyruvate. NanA plays a key role in Neu5Ac catabolism in many pathogenic and bacterial commensals where sialic acid is available as a carbon and nitrogen source...