N-乙酰-D-乳糖胺(N-Acetyl-D-lactosamine,LacNAc)是由半乳糖和N-乙酰葡萄糖构成的一种二糖。是一种天然的结构元件存在于大量复合糖内,发现于牛奶、尿液、胎粪和糖蛋白中。是半乳糖苷酶、岩藻糖基转移酶和唾液酸转移酶的作用底物。用作凝集素抑制糖,来鉴定凝集素。
The ability to generate molecular diversity around a natural carbohydrate ligand taking advantage of the rich chemistry of the nitrile functional group was demonstrated by synthesizing 24 derivatives of N-acetyllactosamine (LacNAc). The disaccharides prepared carried carboxymethyl, amidinomethyl, aminoethyl...
别名:N-乙酰基-D-乳糖胺,LacNAc 分子式:C14H25NO11 分子量:383.4 纯度:>98% 溶解度:DMF: 0.5 mg/ml,DMSO: 30 mg/ml,Ethanol: slightly,PBS (pH 7.2): 10 mg/ml 储存:Store at -20°C 库存:现货 Background N-acetyl-D-Lactosamine is a disaccharide consisting of galactose and N-acetylglucose...
此外,N-乙酰-D-乳糖胺(LacNAc)已被用作多种疾病检测的标志物,在生物化学和生理学领域得到了广泛的研究。 生化和生理效应: N-乙酰-D-乳糖胺(LacNAc)已被发现具有多种生化和生理作用。N-乙酰-D-乳糖胺(LacNAc)除了在细胞间相互作用中起作用外,还被发现可以调节酶的活性,调节基因表达,影响蛋白质的结构和功能。
中文名称:N-乙酰-D-乳糖胺 中文别名:乙酰基乳糖胺 CAS No:32181-59-2 分子式:C14H25NO11 沸点:805.5 °C at 760 mmHg 闪光点:441 °C 折射率:1.623 密度:1.64 外观白色结晶固体 安全说明:26-36/37 UDP-N-acetylgalac
Most of the solvents tested increased the LacNAc synthesis and reduced the undesired side reactions. In order to understand the possible effects of these solvents over the enzyme regioselectivity, we developed a conformational study of the enzyme structure in the presence of a selected bio-solvent ...
Flow cytometry showed that, galectin-3 binding to cells correlates with surface expression of poly N -acetyllactosamine (polylacNAc) but not with other reported ligands, e.g. Thomsen-Friedenreich (T/Tn) antigen. Immobilized galectin-3 promoted adhesion of melanoma cells in a metastasis dependent ...
(LacNAc, type-2 core; Galβ1-4GlcNAc) by a β-1,3 or β-1,6-bond1,2. Recently, LacNAc has also been found as a free disaccharide in human milk, with concentrations that decrease from 310 μg/ml on colostrum to 6.7 μg/m after the first week of lactation3. LacNAc is also a...
Poly-N-acetyllactosamine (Poly-LacNAc, [3Gal1,4GlcNAc1]n) glycans play an essential role in carbohydrate-protein interactions. The synthesis of poly-LacNAc... C Rech,RR Rosencrantz,K K?Enek,... - 《Advanced Synthesis & Catalysis》 被引量: 70发表: 2011年 Chemo-enzymatic modification of ...
Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins. We here present the biofunctionalization of surfaces with poly-LacNAc structures and subsequent binding of ECM glycoproteins. First, we...