Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine. FEBS letters. 2004; 562(1-3):134-140.Gotoh, M., Sato, T., Kiyohara, K., Kameyama, A., Kikuchi, N., Kwon, Y.D., Ishizuka, Y., Iwai, T., Nakanishi, ...
lactose 一种二糖。分子式C12H22O11。学名4-O-β-D-半乳吡喃苷基-D-葡萄吡喃糖。由葡萄糖和半乳糖各一分子缩合失水形成。为哺乳动物乳汁中的主要的糖,人乳含乳糖5%～7%,牛乳含4%。从乳清中得到的为a-乳糖。a-乳糖在93.5℃以上的浓溶液中结晶,得到β-乳糖。从水溶液中结晶时带有一分子结晶水。a型一水合物...
Analysis of the products obtained with GlcNAc and a desialylated and degalactosylated diantennary glycopeptide by 400 MHz 1H-NMR spectroscopy revealed that a GalNAc beta 1-->4GlcNAc (N,N'-diacetyllactosediamine,lacdiNAc) unit was formed. The enzyme can therefore be described as a UDP-GalNAc:...
Apical Golgi localization of N,N′-diacetyllactosediamine synthase, β4GalNAc-T3, is responsible for LacdiNAc expression on gastric mucosa beta1,4-N-acetylgalactosaminyltransferase III (beta4GalNAc-T3), which was recently cloned and identified, exhibits GalNAc transferase activity toward a Glc......
Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H, Molecular cloning and characterization of a novel human β 1,4-N-acetylgalactosaminyltransferase, β 4GalNAc-T3, responsible for the synthesis of N N'-diacetyllactosediamine, GalNAc β 1–4GlcNAc, J Biol Chem 278 , 47534–44 (...
When these structures were presented as sialyl-(2→3)-lactose or as a tryptic peptide from glycophorin A, they were shown to be rather good acceptor substrates for the N-acetyl-β- d-galactosaminyltransferase from human kidney.doi:10.1016/S0008-6215(00)90376-8Piller F...
Hagen FK,Hazes B,Raffo R,Desa D,Tabak LA.Structure-function analysis of the UDP-N-acetyl-D-galactosamine: polypeptideN-acetylgalactosaminyltransferase.Essen tial residue lie in a predicted active site cleft resembling a lactose repressor. Biological Chemistry . 1999...