Several drugs are currently in use as glutathione (GSH) enhancers in clinical, pre-clinical and experimental research. Here we compare the ability of N-acetylcysteine (NAC), 2-oxothiazolidine-4-carboxylic acid (OTC), glutathione ethyl ester (GSH-EE) and N-acetylcysteine ethyl ester (NACET) to...
N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxid... Recent large clinical trials failed to confirm the supposed beneficial effects of N-acetylcysteine (NAC) in preventing oxidative stress-related dise...
N-Acetyl-L-Tyrosine Ethyl Ester N-Acetyl-Leu-Leu-Norleucinal N-Acetyl-Leucine Leucine Norleucinal N-Acetyl-Leucine-Leucine-Methionine N-Acetyl-P-Aminohippuric Acid N-Acetyl-P-Benzoquinone Imine N-Acetyl-Para-Amino-Phenol N-acetyl-seryl-aspartyl-lysyl-proline, acetyl-N-Ser-Asp-Lys-Pro N-Ace...
Bioresorption is another property affected by polymer hydrophobicity/hydrophilicity, since it occurs initially through the hydrolysis of the ester bonds. The high hydrophobicity of the polymer limits water uptake, which decrease the polymer degradation rate [37,45,46]. The results obtained for PGlCL-...
(intermediate product 2). Thus the covalent linkage of NAC to CS would be influenced and the content of free sulfhydryl group would be reduced on CS-NAC. Accordingly, the addition of DMF was to prevent the broken of the ester linkage of intermediate product 1 in water, and subsequently ...
Here we compare the ability of N-acetylcysteine (NAC), 2-oxothiazolidine-4-carboxylic acid (OTC), glutathione ethyl ester (GSH-EE) and N-acetylcysteine ethyl ester (NACET) to increase the intracellular concentration of GSH using primary human umbilical vein endothelial cells (HUVEC) as in vitro...
Kinetic Spectrophotometric Determination of N-acetylcysteine ethyl Ester using Bicinchoninic AcidKuko-Modun, L.Tsikas, D.Kraljevi, T.Bioi, M.Radi, Nj.Bulletin of the Chemists & Technologists of Bosnia & Herzegovina / Glasnik Hemiara i Tehnologa Bosne i Hercegovine...
Giustarini, D.; Milzani, A.; Dalle-Donne, I.; Tsikas, D.; Rossi, R.N-Acetylcysteine ethyl ester (NACET): A novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.Biochem. Pharmacol.2012,84, 1522–1533. [Google Scholar...
USE OF N,S-DIACETYLCYSTEINE-ETHYLESTER (DACEE) FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF VIRAL DISEASESA new use of thiol compounds is disclosed for preparing a pharmaceutical composition for treating virus-induced diseases. In particular, the use of thiol compounds is disclosed ...
Present study was aimed at improving the bioavailability of NAC by conjugating it with morpholinoethanol into a morpholinoethyl ester conjugate (A-2). A-2 was synthesized by DCC coupling and the structure was confirmed by IR, 1H-NMR, 13C-NMR, elemental analysis and mass spectroscopy. This ...