(1) Member (Tip-associated protein, TAP, 616aa) of the evolutionarily conserved nuclear RNA export factor (NXF) family of proteins that mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport ...
Breast cancer is a highly heterogeneous disease. Its intrinsic subtype classification for diagnosis and choice of therapy traditionally relies on the presence of characteristic receptors. Unfortunately, this classification is often not sufficient for pre
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltrans
Accumulation of senescent cells in tissues causes organism aging2,3,4,5. It has been reported that protein synthesis capacity decreases with senescence and aging6,7,8. The mechanism causing a reduced protein translation in senescence is still not well understood. Protein synthesis is an energy ...
PC12 cells were seeded into the wells of 6-well plates pre-coated with poly-D-lysine at a density of 500,000 cells/well and cultured in growth medium for 48 hours. Following this, cells were incubated in serum-depleted medium (1% FBS, 0.5% HS) for an additional 16 hours. Cells were...
The absorbance for each laminin-coated well was normalized against the mean absorbance of BSA-coated wells. Adhesion of ΔPOMGnT1 cells to laminin is represented as relative adhesion in %, considering adhesion of WT cells to laminin as 100%. B, relative cell–cell adhesion of WT and ΔPOMG...
Eine Darstellung dieses komplexen und schwierigen Kapitels kann nur erfolgen entsprechend der Definition der „Osteopathien“ als reaktive Vorgänge des „Organs Knochen“ auf generalisierte Veränderungen seiner biologischen Bedingungen,...
Here, we describe a two-step chemoenzymatic approach for N-glycan-subtype-selective editing on the surface of living cells that consists of a first ‘delete’ step to remove heterogeneous N-glycoforms of a certain subclass and a second ‘insert’ step to assemble a well-defined N-glycan back...
Alagarsamy Pandikumar1, Hong Ngee Lim2,3, Ramasamy Ramaraj1,4 & Nay Ming Huang1 A silver nanoparticle-decorated N,S-co-doped TiO2 nanocomposite was successfully prepared and used as an efficient photoanode in high-performance dye-sensitized solar cells (DSSCs) with N719 dye. Th...
The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand. The invention is based upon the discovery that the alpha 4 beta 1 extracellular matrix receptor promotes ad...