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We found that 1-ARs agonist phenylephrine (Phe) increases pre-synaptic glutamate release probability and the number of released vesicles via interaction with both glutamate release machinery and N-type Ca2+ channels. Our results may provide a cellular and molecular mechanism that helps explain 1-ARs...
optical detection of the interaction of n-type ca2+ channels with g proteins at the single protein leveldoi:10.1016/j.neures.2010.07.2062Toshihide NukadaHiroko NakataTadasaburoh KatanoKumiko HiraiMitsunobu YoshiiNeuroscience Research
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L. et al. G protein-gated inhibitory module of N-type (ca(v)2.2) ca2 þ channels. Neuron 46, 891–904 (2005). 20. Altier, C. et al. The Cavbeta subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat. Neurosci. 14, 173–180 (2011). 21...
产品名称:ω-Conotoxin-MVIIC Blocker of P/Q and N-type Ca2+ channels 产品型号:08CON002-00100 产品展商:其他品牌 产品文档:无相关文档 简单介绍 ω-Conotoxin-MVIIC Blocker of P/Q and N-type Ca2+ channels ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from th...
Since the contribution of ion channels to nerve function depends on their cell surface distribution, we hypothesized that epilepsy might alter VDCC surface densities. To test this idea we mapped the expression and distribution of fluorescent-labeled hippocampal N-type VDCCs (N-VDCCs) in an animal...
These responses were fully blocked by nanomolar concentrations of the omega-conotoxins GVIA, MVIIA, and MVIIC, most likely by inhibiting Ca2+ entry through presynaptic N-type Ca2+ channels controlling the release of ATP. Repeated washout of the toxins allowed the recovery of contractions, except ...
Analysis of different clones provided evidence for the existence of distinct isoforms of N-type channels. High levels of mRNA were found in the pyramidal cell layers CA1, CA2 and CA3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 and 4, in the subiculum and the ...