saprophyticus is a crucial factor for surface hydrophobicity and also gives a first significant functional description of the N-terminal repeats, which in conjunction with the B-repeats form an optimal hydrophobic conformation.Britta KleineLiaqat Ali...
2) long terminal repeats 长末端重复区3) terminal redundancy 末端重复 例句>> 4) N terminus region N末端区域 1. Studies of site directed mutagenesis and chimeric receptors have indicated that the N terminus region of CCR5 is important for chemokines binding, viral fusion, and entry. 实验...
NLRs are modular proteins consisting of an N-terminal domain (NTD), a central NB-ARC domain, and a C-terminal region containing leucine-rich repeats (LRR) or other superstructure-forming repetitive elements (Sarris et al. 2016; Lapin et al. 2022). The NB-ARC domain functions as a switch ...
The N-terminal region of PspA consists of two putative amphipathic helixes (AHs) (see Fig. 1), AHb required for negative control, and AHa required for effector function [19]. The N-terminal AHa (ahA; residues 2–19) is responsible for IM binding and effector function in vivo. The lack...
近期,基础医学院宓文义教授和董城教授两个课题组合作于Nature Communications上发表题为CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation的文章,报道了一种新型的N端降解通路Non-ac/N-degron pathway。在这个通路中,E3...
During the production of a recombinant Plasmodium falciparum circumsporozoite protein in this system, the (NANP) n repeats region at the N-terminus were completely proteolytically degraded. To remove the potential proteolytic site within the recombinant protein, different strategies were tried, including ...
A central observation of this study is that the most conserved N-terminal consensus T/SPLH tetrapeptide motifs, which initiate the helix–turn–helix conformation of the repeats AR2, AR6, AR11, AR12 and AR13, are required for the proper functioning of TRPA1 and distinctly contribute to its...
It is not clear how the length of the repeats is correlated with formation of protein aggregates. By expressing a series of huntingtin constructs encoding various glutamine repeats (23-150 units) in cultured cells we observed N-terminal fragments of huntingtin (amino acids 1-67 and 1-212), ...
To search the volume around the missing N-terminal TPR repeats, a density map was created using molmap in Chimera from the atomic coordinates of the 11.5 TPR units crystal structure, which had been fitted into our map and localised to the poorly resolved N-terminal region21. This density map...
PB-L-TIR/PB-R-TIR: piggyBac left/right terminal inverted repeats; PGK: phosphoglycerate kinase promoter; CAG: cytomegalovirus-actin-globin artificial hybrid promoter; CMV: cytomegalovirus promoter; Puromycin res. cds: Puromycin resistance coding sequence; GFP: green fluorescent protein; pA: ...