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To discover vulnerabilities associated with senescence, we performed large-scale small-interfering RNA (siRNA) screens in normal and senescent human cells (Fig.1a). We first used IMR90 fibroblasts expressing an ER:RAS fusion protein. In the presence of 4-hydroxytamoxifen (4OHT), ER:RAS becomes ...
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One efficient strategy is to design the nanomaterials or nanostructures via reducing the particle size of down to the nanometer scale, which could accommodate or buffer the volume changes, greatly reduce the Fster3aOin4 1National & Local United Engineering Laboratory of Flat Panel Display Technology,...
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(rod:cone ratio = approximately 98:2)35. A rabbit’s eyeball size is similar to that of humans, but rabbit retinal vascular development differs from that of the human eye (melanotic vs. holangiotic)36,37. Numerous studies have employed pigs for large-animal models in the study of ...
Where [Math Processing Error]x<4, the values are presented to-scale. Where [Math Processing Error]x>4, the values are presented not-to-scale. Peptide’s which the literature states possess no hemolytic activity are presented separately, also not-to-scale. Correctly predicted peptides are ...