from a lipid bilayer using infrared irradiation for proteoform-level characterization by native top-down mass spectrometry. This represents a critical development for drug discovery, as the direct role of post-translational modifications in protein–protein and protein–drug interactions can be ...
The different sequences for τα are due to the strong influence of the force constant, which represents the C3v→D3h restoring energy. It is remarkable that the vibronic coupling energy is strongly correlated with the chemical hardness η (an observable quantity), while the stabilization energy ...
Catalytic site-selective functionalization of distal C–H bonds represents a formidable challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C(sp2)–H bonds remains largely unexplored. Here we present a highly para-selective acylation strategy to target ultraremote...
This represents a crucial step toward the goal of developing photonic devices, such as photodetectors and photovoltaic cells, based on Ge1-ySny. Infrared ellipsometry experiments demonstrate high carrier concentrations and excellent resistivities in As(GeH3)3-doped Ge1-ySny. The latter are only ...
Multimerization of enzymes represents one strategy for catalytic subunit stabilization that is often used, for example, in thermophilic organisms. Consistent with this trend, the intracellular bacterial β-N-acetylhexosaminidases are monomeric whereas the extracellular secreted enzymes of fungi and humans ...
Both ferroptosis inhibitors prevented the cytotoxic effects of DHA and DPA in 3D HCT-116 and FaDu tumor spheroids (Figures 5D and S11A). Altogether, these results indicate that preventing PUFA buffering into LDs with DGATi represents an achievable strategy to selectively promote ferroptotic death ...
This represents an extension of our recent studies of the size dependence of the vibrational frequency shift for Ar n HF clusters [J. Chem. Phys. 101, 6359, 10181 (1994)]. The HF vibrational frequency shifts calculated for the two or three lowest‐energy isomers of each cluster size ...
Spider silk has outstanding mechanical properties that surpass man-made materials and represents an attractive material for many potential applications. Orb-weaving spiders are able to synthesize up to seven types of silk for various purposes, including major ampullate, minor ampullate, flagelliform, ac...
The N-terminal sequence of MscL is shown with the region of deleted residues in red. Bar represents 20 G. (d) Calculated mobility parameter at position M94-SL for the different spin-labelled constructs in a,c. (e) A cartoon representation of the electrostatic interaction of the Glu (E6 ...
. Specifically, the OHadscoverage at 0.8 VRHE(where RHE represents reversible hydrogen electrode) is 0.26 (Fig.2d), much higher than Pd/C (0.00042), Pd/N-C (0.06), and Pd+Co@N-C (0.11). The electron-deficient state of Pd is beneficial for the oxidation/removal of CO (poisoning ...