并且 OPN 与 CD44v 交往并且调制在 CD44 和玻尿的酸之间的相互作用[1 ] .在它被凝血酵素或矩阵 metalloproteases (MMP-3/MMP-7 ) 劈开以后,当前的研究证明了 OPN 的生物活动被提高[3 ] .OPN 能把受体绑在 integrin 并且调整房间坚持,移植,增长,和幸存,等等.在劈开的 OPN 的 RGD 和 SVVYGLR 的结构被...
· CD44v6 ELISA CD44v6 · CD44 ELISA CD44 · CD42 ELISA CD42 · 白细胞分化抗原40配体 ELISA CD40L · CD4 ELISA CD4 · 白细胞分化抗原23 ELISA CD23 · 白细胞分化抗原14 ELISA CD14 · CD11a ELISA CD11a · C多肽 ELISA CCP Peptide · 组织蛋白酶 ELISA Cathepsin ·β-联蛋白...
et al. Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN–CD44V interaction enhances survival in gastrointestinal cancer cells. Cancer Res. 67, 2089–2097 (2007). CAS PubMed Google Scholar Brakebusch, C., Hirsch, E., Potocnik, A. & Fassler, R. ...
简述骨桥蛋白的自身调节方式 OPN有磷酸化和去磷酸化两种形式,磷酸化修饰是影响OPN活性的一个重要因素。多种激酶对OPN中丝氨酸、苏氨酸残基发生磷酸化有不同部位,发生蛋白磷酸化部位不同可能是其组织特异性的原因之一。磷酸化后的OPN与细胞表面整合素受体结合,而去磷酸化OPN则能与CD44受体结合,从而引起不同的效应。完...
KS14304 人CD44分子(CD44)ELISA试剂盒KS12047 人芳香烃受体(AhR)ELISA试剂盒KS17879 猪程序性死亡分子1(PD1)ELISA试剂盒KS15402 人异质性胞核核糖核蛋白M(hnRNPM)ELISA试剂盒KS11803 人白介素3(IL-3)ELISA试剂盒KS15996 鸡Ⅱ型胶原(ColⅡ)ELISA试剂盒KS10319 大鼠雄烯二酮(ASD)ELISA试剂盒KS11425 人...
OPN in OA. Using morphological comparisons, we found that the cartilage was severely worn-out and there was a significant loss of the cartilage matrix in OA. OPN, CD44, and hyaluronic acid (HA) synthase 1 (HAS1) were highly expressed, and the anabolism of HA was significantly higher in ...
Even though we could not identify tumors before they were more than 2 mm in size, our analysis nevertheless revealed an overexpression of a number of interesting genes involved in growth and motility, the most overexpressed of which was osteopontin (OPN), a phosphoprotein that has been implicated...
一是以分子内RGD基元与整合蛋白(integrin)家族分子结合;二是与细胞表面粘附性糖蛋白CD44以非RGD依赖方式结合。两种作用方式均通过激活细胞内特异性信号传导系统而介导细胞粘附、迁移和增殖。OPN与整合素受体结合后启动信号转导级联反应,促进基因表达的改变,并诱导NF-КB活性,OPN能诱导骨骼蛋白的粘附斑激酶(FAK)和桩蛋白...
并且进一步研究表明,这些转移性乳腺癌干细胞膜上的CD44v可以与肺组织中的Osteopontin (OPN)相互作用,在OPN的刺激下增强肿瘤细胞的浸润能力,从而促进肿瘤细胞向肺转移。在乳腺癌临床样本中,ESRP1和CD44v的高表达,而不是CD44s和总CD44的表达,与病人发生远端转移的不良预后正相关。
EG intake promoted the expression of OPN and CD44 in the kidney, while LPN1 supplement inhibited the expressions of OPN and CD44 at mRNA (Figure 1B) and protein (Figure 1C) levels in EG-induced hyperoxaluric rats. Taken together, these data suggested that LPN provided a protection against...