METHYL aspartateMETHYL aspartate receptorsATTENTIONNMDA receptors (NMDARs) may be crucial to working memory (WM). Computational models predict that they sustain neural firing and produce associative memory, which may underpin maintaining and binding information, respectively. W...
The present invention is based in part on the surprising discovery that Tanshinones from Salvia miltiorrhiza act as allosteric high-potency N-methyl-D-aspartate receptor antagonists. Pharmacological blockade of excessive activation of N-methyl-D-aspartate receptors (NMDARs) greatly reduces ischemic injury...
N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory neurotransmission and synaptic plasticity. GluN2A and GluN2B, two predominant Glu2N subunits of NMDARs in the hippocampus and the cortex, display distinct clustered distribution patterns and mobility at synaptic and extrasynaptic site...
Note:NMDARs: N-methyl-d-aspartate receptors. NR: subunits of NMDARs. FT3: free triiodothyronine. TSH: thyroid stimulating hormone. TRH: thyrotropin-releasing hormone. TGAb: thyroglobulin antibody. TPOAb: thyroid peroxidase antibody. P-values: obtained using the binary logistic regression analysis. ...
The N-Methyl-D-Aspartate Receptor (NMDAR) and neuronal-glial-cytokine interactions that initiate and maintain inflammatory painFollowing injury, NMDAR activation in spinal cord dorsal horn (SCDH) neurons facilitates the generation of pain in response to low threshold inputs (allodynia). The NMDAR ...
N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated cation channels that are expressed throughout the brain and play essential role in brain functioning. Diversity of the subunits and of their spatio-temporal expression imparts d... N Burnashev,P Szepetowski - 《Current Opinion in Phar...
Regulation of N-methyl-D-aspartate receptors by astrocytic D-serine D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurot... SHR Oliet - 《Neuroscience》 被引量: 0发表: 2009年 加载更多来源...
Switching of N-methyl-D-aspartate (NMDA) receptor-favorite intracellular signal pathways from ERK1/2 to p38 MAPK leads to developmental changes in NMDA neu... Excitotoxicity mediated by overactivation of N-methyl-D-aspartate receptors (NMDARs) has been implicated in a variety of neuropathologica...
Postsynaptic density-95 (PSD-95) protein anchors glutamatergic N-methyl-D-aspartate (NMDA) receptors (NMDAR) to intracellular signaling molecules, at the level of neuronal synapses, thus modulating the specificity of pain-related glutamatergic neurotransmission signaling cascades7,8. Recent studies have ...
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key roles in excitatory s... P Paoletti,J Neyton - 《Current Opinion in Pharmacology》 被引量: 831发表: 2007年 Performance of Philips Gemini TF PET/CT Scanner ...