N-glycan Biosynthesis: Basic Principles and Factors Affecting Its OutcomeEndoplasmic reticulumGolgi apparatusN-glycosylationOrganelle homeostasisCarbohydrate chains are the most abundant and diverse of nature's biopolymers and represent one of the four fundamental macromolecular building blocks of life together ...
N-Glycan biosynthesis 来自 ResearchGate 喜欢 0 阅读量: 373 作者:G Dall'Olio,P Gagneux 摘要: Humans and great apes (collectively known as the hominoids) share genomes of very similar size. Humans and chimpanzees shared a common ancestor 5–6 million years ago. Changes in regulatory regions ...
Deficiencies in the pathway of N-glycan biosynthesis lead to severe multisystem diseases, known as congenital disorders of glycosylation (CDG). The clinica... B Schenk,T Imbach,CG Frank,... - 《Journal of Clinical Investigation》 被引量: 169发表: 2002年 Cloning and expression of a specific ...
Alterations of O-glycan biosynthesis in human colon cancer tissues Yang Ji-Mao,Byrd James C.,Siddiki Bader B.,... - 《Glycobiology》 - 1994 - 被引量: 369 Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in ...
N-Glycans are a common class of glycans10. Early steps ofN-glycan biosynthesis occurring in the ER are highly conserved among all eukaryotes to produce the commonN-glycan intermediates, and late steps in the Golgi apparatus bring about species-, tissue-, protein-, and disease-specificN-glycans...
glycan biosynthesis pathway. A major challenge posed for the glycomic analysis of biological samples is the immense complexity of the glycome. This complexity is reflected in the vast number of different structures present, including glycan isomers, and in the broad dynamic range of glycan abunda...
Chapter2 N-linkedGlycosylation AlleukaryoticcellsproduceN-glycans.N-linkedglycosylationisthebestunderstoodroutetoproteinglycosylation.ThemolecularcloningofvertebrateglycosyltransferasesandglycosidasegenesinvolvedinN-glycanbiosynthesisbeganinthe1980sandcontinuestothepresent.2.1DiverseN-linkedglycanshaveacommoncorestructure N-...
because they indicate the extent of each N-glycan's microheterogeneity. Several glycosyltransferases, which participate in N-glycan biosynthesis, might have gathered in each inner cell near the elongating sugar chain at that time. Therefore, each microheterogeneity configuration occupies only a limited,...
Glycobiology Chart2.N-linkedGlycosylation GuLi MajorGlycanClassesinAnimalCells HYALURONANGLYCOSAMINOGLYCANS P CHONDROITINSULFATE SSSSer-O- HEPARANSULFATE SSSNSS S -O-SerNS N-LINKEDCHAINS O-LINKEDCHAIN SAcP Proteoglycan GLYCOPHOSPHOLIPIDEtnANCHOR PNAsnNH2INOSITOL OSer/Thr NAsn GLYCOSPHINGOLIPID Ac Glycoprotein...
For the characterization ofN-glycans, a MassHunter Personal Compound Database and Library (PCDL) was created. This theoreticalN-glycan database was established based on the knowledge of mammalian serumN-glycan biosynthesis and the possible modifications9,10,19,31. As a result, a theoretical library...