N-glycan Biosynthesis: Basic Principles and Factors Affecting Its OutcomeEndoplasmic reticulumGolgi apparatusN-glycosylationOrganelle homeostasisCarbohydrate chains are the most abundant and diverse of nature's biopolymers and represent one of the four fundamental macromolecular building blocks of life together ...
Control of T Cell-mediated Autoimmunity by Metabolite Flux to N-Glycan Biosynthesis Autoimmunity is a complex trait disease where the environment influences susceptibility to disease by unclear mechanisms. T cell receptor clustering and si... A Grigorian,SU Lee,W Tian,... - 《Journal of ...
In addition, metabolic engineering efforts undertaken to modify insect, yeast and plant -glycan processing pathways have yielded sialylated complex-type -glycans in insect cells, and galactosylated -glycans in yeasts and plants, indicating that cell lines can be engineered to produce mammalian-like ...
N-glycan biosynthesisN -acetylglucosaminyltransferase (GnT)-IV catalyzes the formation of the GlcNAcβ1-4 branch on the GlcNAcβ1-2Manα1-3 arm of the core structure of N -glycans. Two human GnT-IV isozymes (GnT-IVa and GnT-IVb) had been identified, which exhibit different expression ...
The enzymes involved in plant N-glycan biosynthesis and processing are still not well defined and the mechanism of their genetic regulation is almost completely unknown. In this paper we describe our first attempt to understand the N-linked glycosylation mechanism in a plant species by using the ...
Often such glycans are considered intermediates in N-glycan biosynthesis, but the presence of high mannose-type N-glycans on mature viral glycoproteins from MDCK cells are consistent with these being mature structures, and not intermediates17. For complex-type N-glycans, our results demonstrate that...
IntroductionThe Roads which Lead to Complex N-GlycansGlycosyltransferases Involved in the Synthesis of Complex N-Glycan AntennaeBiosynthesis of O-GlycansCo... I Brockhausen,H Schachter - Glycosciences: Status and Perspectives 被引量: 56发表: 2008年 Glycosyltransferases Involved in O-fucose Glycan Synthe...
Chapter2 N-linkedGlycosylation AlleukaryoticcellsproduceN-glycans.N-linkedglycosylationisthebestunderstoodroutetoproteinglycosylation.ThemolecularcloningofvertebrateglycosyltransferasesandglycosidasegenesinvolvedinN-glycanbiosynthesisbeganinthe1980sandcontinuestothepresent.2.1DiverseN-linkedglycanshaveacommoncorestructure N-...
This enzyme is capable of trimming high mannose oligosaccharides to Man5GlcNAc2 duringN-glycan biosynthesis. Human α1,2-mannosidase IC requires calcium for activity and is inhibited by 1-deoxymannojirimycin and kifunensine; thus, it possesses the characteristic properties of class I α1,2-...
Glycobiology Chart2.N-linkedGlycosylation GuLi MajorGlycanClassesinAnimalCells HYALURONANGLYCOSAMINOGLYCANS P CHONDROITINSULFATE SSSSer-O- HEPARANSULFATE SSSNSS S -O-SerNS N-LINKEDCHAINS O-LINKEDCHAIN SAcP Proteoglycan GLYCOPHOSPHOLIPIDEtnANCHOR PNAsnNH2INOSITOL OSer/Thr NAsn GLYCOSPHINGOLIPID Ac Glycoprotein...