AcylationAminesCobaltAmidesAn efficient, practical, CoII‐catalyzed N ‐acylation reaction of various amines using readily available and inexpensive DMF and other amides as carbonyl sources is described. Abstract A practical protocol has been developed for a Co(OAc)2·4H2O‐catalyzed transamidation ...
acylationazomethine ylidesheterocycleszirconiumThis procedure can be used as an alternative method to the Reissert-type reduction of azaaromatics.doi:10.1002/chin.201531198Saito, AkioUematsu, YukiSudo, KoheiHanzawa, YujiJohn Wiley & Sons, Ltd.Cheminform...
M. A model for the reaction mechanism of the transglutaminase 3 enzyme. Exp. Mol. Med. 35, 228–242 (2003). 38. Murthy, S. N. P., Lukas, T. J., Jardetzky, T. S. & Lorand, L. Selectivity in the post-translational, transglutaminase-dependent acylation of lysine residues. ...
Chemoselectivity refers to the preferential reaction of a single chemical reagent with one of two or more different functional groups1. One of the most formidable challenges presented to synthetic chemists involves achieving high levels of chemoselectivity and regioselectivity amongst the myriad of reactive...
Acylation of human insulin was studied using, C/sub 2/ and C/sub 12/ transfer reagents, N-succinimidyl acetate and N-succinimidyl dodecanoate (lauryl) respectively. In general, the acylation reaction was more specific at high pH values (12.00) for the modification of the epsilon-amino group ...
In contrast to recent significant progress in the development of catalytic methodologies for nitrogen acylations, syntheses of N-acyl sulfoximines have been slow to evolve, and still largely rely on the use of stoichiometric amounts of activating reagents. Here we describe the direct acylation of th...
An Unprecedented N-Transacylation Reaction of 2-Acetamido-2-deoxy-α-D-glucopyranosides.doi:10.1002/chin.200417194carbohydratesamination, N-alkylation, N-arylationYingxia LiInst. Food, Ocean Univ. China, Tsingtao 266003, Peop. Rep. ChinaChunxia Li...
The introduction of a dialkylaminoalkylamino chain in the 6-position of 1,3-dimethyluracil modifies the regiospecificity of the acylation reaction to give N-6 acylated compounds. This reversal in acylation is induced by an intramolecular proton-transfer which introduces a change in the electron ...
Mariggiò found that cPLA2α was involved in the conversion of PI to LPI and glycerophosphoinositol by sequential deacylation reactions [609]. Alternatively, we presumed that LPI may be formed from PI by the reverse reaction of acyl-CoA:LPI acyltransferase [66,67,69]. Table 10. Compositions ...
Keywords: acylation; antibiotics; benzotriazolides; drug research 1. Introduction Effective antibiotics are needed to combat the growing bacterial resistance [1]. Cephalosporins are an important class of antimicrobials with a broad-spectrum of activity and a favourable safety profile [2]. The ...